An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction

R Singh, M Ierapetritou, R Ramachandran - International journal of …, 2012 - Elsevier
A novel manufacturing strategy based on continuous processing integrated with online
monitoring tools coupled with efficient automatic feedback control system is highly desired …

Real time monitoring of powder blend bulk density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process

R Singh, AD Román-Ospino, RJ Romañach… - International journal of …, 2015 - Elsevier
The pharmaceutical industry is strictly regulated, where precise and accurate control of the
end product quality is necessary to ensure the effectiveness of the drug products. For such …

[HTML][HTML] A combined feed-forward/feed-back control system for a QbD-based continuous tablet manufacturing process

R Singh, FJ Muzzio, M Ierapetritou, R Ramachandran - Processes, 2015 - mdpi.com
Continuous pharmaceutical manufacturing together with PAT (Process Analytical
Technology) provides a suitable platform for automatic control of the end product quality as …

Development and implementation of an advanced model predictive control system into continuous pharmaceutical tablet compaction process

A Bhaskar, FN Barros, R Singh - International journal of pharmaceutics, 2017 - Elsevier
In the context of continuous pharmaceutical oral dosage manufacturing, a control system is
essential to ensure that the critical quality attributes (CQAs) are maintained within the …

System-wide hybrid MPC–PID control of a continuous pharmaceutical tablet manufacturing process via direct compaction

R Singh, M Ierapetritou, R Ramachandran - European Journal of …, 2013 - Elsevier
The next generation of QbD based pharmaceutical products will be manufactured through
continuous processing. This will allow the integration of online/inline monitoring tools …

A systematic framework for onsite design and implementation of a control system in a continuous tablet manufacturing process

R Singh, A Sahay, F Muzzio, M Ierapetritou… - Computers & chemical …, 2014 - Elsevier
A novel manufacturing strategy based on continuous processing integrated with
online/inline monitoring tools coupled with an advanced control system is highly desired for …

Closed-loop feedback control of a continuous pharmaceutical tablet manufacturing process via wet granulation

R Singh, D Barrasso, A Chaudhury, M Sen… - Journal of …, 2014 - Springer
The wet granulation route of tablet manufacturing in a pharmaceutical manufacturing
process is very common due to its numerous processing advantages such as enhanced …

Implementation of an advanced hybrid MPC–PID control system using PAT tools into a direct compaction continuous pharmaceutical tablet manufacturing pilot plant

R Singh, A Sahay, KM Karry, F Muzzio… - International journal of …, 2014 - Elsevier
It is desirable for a pharmaceutical final dosage form to be manufactured through a quality
by design (QbD)-based approach rather than a quality by testing (QbT) approach. An …

Modeling and control of roller compaction for pharmaceutical manufacturing. Part I: Process dynamics and control framework

SH Hsu, GV Reklaitis… - Journal of Pharmaceutical …, 2010 - Springer
We derive a dynamic model for roller compaction process based on Johanson's rolling
theory, which is used to predict the stress and density profiles during the compaction and the …

Continuous manufacturing of extended release tablets via powder mixing and direct compression

T Ervasti, SP Simonaho, J Ketolainen… - International journal of …, 2015 - Elsevier
The aim of the current work was to explore continuous dry powder mixing and direct
compression for manufacturing of extended release (ER) matrix tablets. The study was span …