Distributed amylin receptor signaling and its influence on motivated behavior

KA Kern, EG Mietlicki-Baase - Physiology & behavior, 2020 - Elsevier
The intake-and body weight-suppressive hormone amylin exerts effects on energy balance
control at a variety of nuclei within the brain, including sites that have been referred to in the …

Amylin activates distributed CNS nuclei to control energy balance

EG Mietlicki-Baase, MR Hayes - Physiology & behavior, 2014 - Elsevier
Amylin is a pancreas-derived neuropeptide that acts in the central nervous system (CNS) to
reduce food intake. Much of the literature describing the anorectic effects of amylin are …

Palatable food access impacts expression of amylin receptor components in the mesocorticolimbic system

H Nashawi, TJ Gustafson… - Experimental …, 2020 - Wiley Online Library
New Findings What is the central question of this study? We tested whether intra‐nucleus
accumbens core amylin receptor (AmyR) activation suppresses feeding and evaluated …

Brainstem mechanisms of amylin-induced anorexia

CS Potes, TA Lutz - Physiology & behavior, 2010 - Elsevier
Amylin is secreted by pancreatic beta-cells and is believed to be a physiological signal of
satiation. Amylin's effect on eating has been shown to be mediated via a direct action at the …

Amylin acts in the lateral dorsal tegmental nucleus to regulate energy balance through gamma-aminobutyric acid signaling

DJ Reiner, EG Mietlicki-Baase, DR Olivos… - Biological …, 2017 - Elsevier
Background The pancreatic-and brain-derived hormone amylin promotes negative energy
balance and is receiving increasing attention as a promising obesity therapeutic. However …

Central amylin signaling and the regulation of energy homeostasis

PA Rushing - Current pharmaceutical design, 2003 - ingentaconnect.com
Amylin is a 37-amino acid peptide hormone that is co-secreted with insulin by pancreatic B
cells in response to food intake. Exogenous amylin potently and dosedependently reduces …

Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake

EG Mietlicki-Baase, LE Rupprecht, DR Olivos… - …, 2013 - nature.com
The ability of amylin, a pancreatic β-cell-derived neuropeptide, to promote negative energy
balance has been ascribed to neural activation at the area postrema. However, despite …

Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior

EG Mietlicki-Baase, LE McGrath, K Koch-Laskowski… - …, 2017 - Elsevier
Amylin is produced in the pancreas and the brain, and acts centrally to reduce feeding and
body weight. Recent data show that amylin can act in the ventral tegmental area (VTA) to …

Central amylin acts as an adiposity signal to control body weight and energy expenditure

PY Wielinga, C Löwenstein, S Muff, M Munz… - Physiology & …, 2010 - Elsevier
The pancreatic B-cell hormone amylin has been proposed to be both a satiation signal and
an adiposity signal. The effects of peripheral amylin on energy balance are well …

The role of amylin in the control of energy homeostasis

TA Lutz - … journal of physiology-regulatory, integrative and …, 2010 - journals.physiology.org
Amylin is an important player in the control of nutrient fluxes. Amylin reduces eating via a
meal size effect by promoting meal-ending satiation. This effect seems to depend on a direct …