[HTML][HTML] Drug repurposing: an effective tool in modern drug discovery

VS Kulkarni, V Alagarsamy, VR Solomon… - Russian Journal of …, 2023 - Springer
Drug repurposing is using an existing drug for a new treatment that was not indicated before.
It has received immense attention during the COVID-19 pandemic emergency. Drug …

[HTML][HTML] Repurposing therapeutics for COVID-19: Rapid prediction of commercially available drugs through machine learning and docking

S Mohapatra, P Nath, M Chatterjee, N Das, D Kalita… - Plos one, 2020 - journals.plos.org
Background The outbreak of the novel coronavirus disease COVID-19, caused by the SARS-
CoV-2 virus has spread rapidly around the globe during the past 3 months. As the virus …

[图书][B] Drug repurposing: hypothesis, molecular aspects and therapeutic applications

FA Badria - 2020 - books.google.com
Drug repurposing or drug repositioning is a new approach to presenting new indications for
common commercial and clinically approved existing drugs. For example, chloroquine, an …

Decoding Connectivity Map-based drug repurposing for oncotherapy

Y Zhao, X Chen, J Chen, X Qi - Briefings in Bioinformatics, 2023 - academic.oup.com
The rising global burden of cancer has driven considerable efforts into the research and
development of effective anti-cancer agents. Fortunately, with impressive advances in …

Drug repositioning based on similarity constrained probabilistic matrix factorization: COVID-19 as a case study

Y Meng, M Jin, X Tang, J Xu - Applied soft computing, 2021 - Elsevier
The novel coronavirus disease 2019 (COVID-19) pandemic has caused a massive health
crisis worldwide and upended the global economy. However, vaccines and traditional drug …

[HTML][HTML] Network-based drug repurposing for HPV-associated cervical cancer

F Ahmed, YJ Yang, A Samantasinghar, YW Kim… - Computational and …, 2023 - Elsevier
In women, cervical cancer (CC) is the fourth most common cancer around the world with
average cases of 604,000 and 342,000 deaths per year. Approximately 50% of high-grade …

Deep learning identifies explainable reasoning paths of mechanism of action for drug repurposing from multilayer biological network

J Yang, Z Li, WKK Wu, S Yu, Z Xu, Q Chu… - Briefings in …, 2022 - academic.oup.com
The discovery and repurposing of drugs require a deep understanding of the mechanism of
drug action (MODA). Existing computational methods mainly model MODA with the protein …

[HTML][HTML] Drug repurposing for viral infectious diseases: how far are we?

B Mercorelli, G Palù, A Loregian - Trends in microbiology, 2018 - cell.com
Despite the recent advances in controlling some viral pathogens, most viral infections still
lack specific treatment. Indeed, the need for effective therapeutic strategies to combat 'old' …

[HTML][HTML] Artificial intelligence in COVID-19 drug repurposing

Y Zhou, F Wang, J Tang, R Nussinov… - The Lancet Digital …, 2020 - thelancet.com
Drug repurposing or repositioning is a technique whereby existing drugs are used to treat
emerging and challenging diseases, including COVID-19. Drug repurposing has become a …

A computational approach to drug repurposing using graph neural networks

S Doshi, SP Chepuri - Computers in Biology and Medicine, 2022 - Elsevier
Drug repurposing is an approach to identify new medical indications of approved drugs. This
work presents a graph neural network drug repurposing model, which we refer to as …