[HTML][HTML] Overexpression of HuR, a nuclear–cytoplasmic shuttling protein, increases the in vivo stability of ARE‐containing mRNAs

XC Fan, JA Steitz - The EMBO journal, 1998 - embopress.org
The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted
for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated …

[HTML][HTML] Identification of HuR as a protein implicated in AUUUA‐mediated mRNA decay

VE Myer, XC Fan, JA Steitz - The EMBO journal, 1997 - embopress.org
Expression of many proto‐oncogenes, cytokines and lymphokines is regulated by targeting
their messenger RNAs for rapid degradation. Essential signals for this control are AU‐rich …

HuR and mRNA stability

CM Brennan, JA Steitz* - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
An important mechanism of posttranscriptional gene regulation in mammalian cells is the
rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in …

Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization

CYA Chen, N Xu, AB Shyu - Molecular and cellular biology, 2002 - Taylor & Francis
Human RNA-binding protein HuR, a nucleocytoplasmic shuttling protein, is a ubiquitously
expressed member of the family of Hu proteins, which consist of two N-terminal RNA …

Tissue distribution of AU-rich mRNA-binding proteins involved in regulation of mRNA decay

JY Lu, RJ Schneider - Journal of Biological Chemistry, 2004 - ASBMB
Short lived cytokine and proto-oncogene mRNAs are destabilized by an A+ U-rich element
(ARE) in the 3′-untranslated region. Several regulatory proteins bind to AREs in cytokine …

AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation

XC Fan, VE Myer, JA Steitz - Genes & development, 1997 - genesdev.cshlp.org
AU-rich elements (AREs, usually containing repeated copies of AUUUA), when present in
the 3′-untranslated regions (UTRs) of many mammalian mRNAs, confer instability on their …

Protein ligands to HuR modulate its interaction with target mRNAs in vivo

CM Brennan, IE Gallouzi, JA Steitz - The Journal of cell biology, 2000 - rupress.org
AU-rich elements (AREs) present in the 3′ untranslated regions of many protooncogene,
cytokine, and lymphokine messages target them for rapid degradation. HuR, a ubiquitously …

[HTML][HTML] RNA stabilization by the AU‐rich element binding protein, HuR, an ELAV protein

SSY Peng, CYA Chen, N Xu, AB Shyu - The EMBO journal, 1998 - embopress.org
An important paradigm for post‐transcriptional regulation is the control of cytoplasmic mRNA
stability mediated by AU‐rich elements (AREs) in the 3′ untranslated region of transcripts …

HNS, a nuclear-cytoplasmic shuttling sequence in HuR

XC Fan, JA Steitz - Proceedings of the National Academy of …, 1998 - National Acad Sciences
Proteins are transported into and out of the cell nucleus via specific signals. The two best-
studied nuclear transport processes are mediated either by classical nuclear localization …

HuR binding to cytoplasmic mRNA is perturbed by heat shock

IE Gallouzi, CM Brennan… - Proceedings of the …, 2000 - National Acad Sciences
AU-rich elements (AREs) located in the 3′ untranslated region target the mRNAs encoding
many protooncoproteins, cytokines, and lymphokines for rapid degradation. HuR, a …