Background Differences in linkage disequilibrium and in allele substitution effects of QTL
(quantitative trait loci) may hinder genomic prediction across populations. Our objective was …

Background Molecular marker information is a common source to draw inferences about the
relationship between genetic and phenotypic variation. Genetic effects are often modelled …

Predicting the accuracy of estimated genomic values using genome-wide marker
information is an important step in designing training populations. Currently, different …

Genomic prediction using multi-allelic haplotype models improved the prediction accuracy
for all seven human phenotypes, the normality transformed high density lipoproteins, low …

Important knowledge about the determinants of complex human phenotypes can be
obtained from the estimation of heritability, the fraction of phenotypic variation in a …

Abstract Knowledge of simulated genetic effects facilitates interpretation of methodological
studies. Genetic interactions for common disorders are likely numerous and weak. Using the …

Average effects of alleles can show considerable differences between populations. The
magnitude of these differences can be measured by the additive genetic correlation …

Both direct genetic effects (effects of alleles in an individual on that individual) and indirect
genetic effects—effects of alleles in an individual (eg parents) on another individual (eg …

The traditional quantitative genetics model was used as the unifying approach to derive six
existing and new definitions of genomic additive and dominance relationships. The …

Motivation For many traits, causal loci uncovered by genetic mapping studies explain only a
minority of the heritable contribution to trait variation. Multiple explanations for this 'missing …