We introduce this communication with a brief outline of the historical landmarks in genetic
modeling, especially concerning epistasis. Then, we present methods for the use of genetic …

Although research effort is being expended into determining the importance of epistasis and
epistatic variance for complex traits, there is considerable controversy about their …

The H-matrix best linear unbiased prediction (HBLUP) method has been widely used in
livestock breeding programs. It can integrate all information, including pedigree, genotypes …

Background Epistasis marker effect models incorporating products of marker values as
predictor variables in a linear regression approach (extended GBLUP, EGBLUP) have been …

Power calculation is a necessary step when planning genome-wide association studies
(GWAS) to ensure meaningful findings. Statistical power of GWAS depends on the genetic …

Background Metafounders are pseudo-individuals that encapsulate genetic heterozygosity
and relationships within and across base pedigree populations, ie ancestral populations …

Dominance genetic effects are rarely included in pedigree-based genetic evaluation. With
the availability of single nucleotide polymorphism markers and the development of genomic …

Fisher's partitioning of genotypic values and genetic variance is highly relevant in the current
era of genome-wide association studies (GWASs). However, despite being more than a …

Background The influence of linkage disequilibrium (LD), epistasis, and inbreeding on
genotypic variance continues to be an important area of investigation in genetics and …

This manuscript delves into the intersection of genomics and phenotypic prediction, focusing
on the statistical innovation required to navigate the complexities introduced by noisy …