The carbon− fluorine bond is the strongest covalent bond in organic chemistry, yet
fluoroacetate dehalogenases can readily hydrolyze this bond under mild physiological …

Fluorine-containing compounds are widely used because they have properties required in
textiles and coatings for electronic, automotive, and outdoor products. However, fluorinated …

Fluorine forms the strongest single bond to carbon with the highest bond dissociation energy
among natural products. However, fluoroacetate dehalogenases (FADs) have been shown …

Fluoroacetate dehalogenase catalyzes the hydrolytic defluorination of fluoroacetate to
produce glycolate. The enzyme is unique in that it catalyzes the cleavage of a carbon …

The capacity to defluorinate polyfluorinated organic compounds is a rare phenotype in
microbes but is increasingly considered important for maintaining the environment. New …

The catalytic mechanisms of fluoroacetate dehalogenase (FAcD) toward substrates
fluoroacetate and chloroacetate were studied by a combined quantum mechanics/molecular …

The introduction of fluorine atoms into organic molecules has received considerable
attention as these organofluorines have often found widespread applications in bioorganic …

The high substrate specificity of fluoroacetate dehalogenase was explored by using
crystallographic analysis, fluorescence spectroscopy, and theoretical computations. A crystal …

The biological dehalogenation of fluoroacetate carried out by fluoroacetate dehalogenase is
discussed by using quantum mechanical/molecular mechanical (QM/MM) calculations for a …

Fluorochemicals are persistent, bioaccumulative, and toxic compounds that are widely
tributed in the environment. Developing efficient biodegradation strategies to decompose …