Rapid discovery of novel prophages using biological feature engineering and machine learning

K Sirén, A Millard, B Petersen… - NAR genomics and …, 2021 - academic.oup.com
Prophages are phages that are integrated into bacterial genomes and which are key to
understanding many aspects of bacterial biology. Their extreme diversity means they are …

Prophage Hunter: an integrative hunting tool for active prophages

W Song, HX Sun, C Zhang, L Cheng… - Nucleic acids …, 2019 - academic.oup.com
Identifying active prophages is critical for studying coevolution of phage and bacteria,
investigating phage physiology and biochemistry, and engineering designer phages for …

PhiSpy: a novel algorithm for finding prophages in bacterial genomes that combines similarity- and composition-based strategies

S Akhter, RK Aziz, RA Edwards - Nucleic acids research, 2012 - academic.oup.com
Prophages are phages in lysogeny that are integrated into, and replicated as part of, the
host bacterial genome. These mobile elements can have tremendous impact on their …

Mining of thousands of prokaryotic genomes reveals high abundance of prophages with a strictly narrow host range

G López-Leal, LC Camelo-Valera… - Msystems, 2022 - Am Soc Microbiol
Phages and prophages are one of the principal modulators of microbial populations.
However, much of their diversity is still poorly understood. Here, we extracted 33,624 …

DBSCAN-SWA: an integrated tool for rapid prophage detection and annotation

R Gan, FX Zhou, Y Si, H Yang, C Chen, C Ren… - Frontiers in …, 2022 - frontiersin.org
As an intracellular form of a bacteriophage in the bacterial host genome, a prophage usually
integrates into bacterial DNA with high specificity and contributes to horizontal gene transfer …

DEPhT: a novel approach for efficient prophage discovery and precise extraction

CH Gauthier, L Abad, AK Venbakkam… - Nucleic Acids …, 2022 - academic.oup.com
Advances in genome sequencing have produced hundreds of thousands of bacterial
genome sequences, many of which have integrated prophages derived from temperate …

PhageWeb–Web interface for rapid identification and characterization of prophages in bacterial genomes

AL Sousa, D Maués, A Lobato, EF Franco… - Frontiers in …, 2018 - frontiersin.org
This study developed a computational tool with a graphical interface and a web-service that
allows the identification of phage regions through homology search and gene clustering. It …

Phage hunters: Computational strategies for finding phages in large-scale 'omics datasets

BL Hurwitz, A Ponsero, J Thornton Jr, JM U'Ren - Virus research, 2018 - Elsevier
A plethora of tools exist for identifying phage sequences in bacterial genomes, single cell
amplified genomes, and host-associated and environmental metagenomes. Yet because the …

Phigaro: high-throughput prophage sequence annotation

EV Starikova, PO Tikhonova, NA Prianichnikov… - …, 2020 - academic.oup.com
Phigaro is a standalone command-line application that is able to detect prophage regions
taking raw genome and metagenome assemblies as an input. It also produces dynamic …

Prophage genomics reveals patterns in phage genome organization and replication

HS Kang, K McNair, DA Cuevas, BA Bailey, AM Segall… - BioRxiv, 2017 - biorxiv.org
Temperate phage genomes are highly variable mosaic collections of genes that infect a
bacterial host, integrate into the host's genome or replicate as low copy number plasmids …