Rapid discovery of novel prophages using biological feature engineering and machine learning
Prophages are phages that are integrated into bacterial genomes and which are key to
understanding many aspects of bacterial biology. Their extreme diversity means they are …
understanding many aspects of bacterial biology. Their extreme diversity means they are …
Prophage Hunter: an integrative hunting tool for active prophages
Identifying active prophages is critical for studying coevolution of phage and bacteria,
investigating phage physiology and biochemistry, and engineering designer phages for …
investigating phage physiology and biochemistry, and engineering designer phages for …
PhiSpy: a novel algorithm for finding prophages in bacterial genomes that combines similarity- and composition-based strategies
S Akhter, RK Aziz, RA Edwards - Nucleic acids research, 2012 - academic.oup.com
Prophages are phages in lysogeny that are integrated into, and replicated as part of, the
host bacterial genome. These mobile elements can have tremendous impact on their …
host bacterial genome. These mobile elements can have tremendous impact on their …
Mining of thousands of prokaryotic genomes reveals high abundance of prophages with a strictly narrow host range
G López-Leal, LC Camelo-Valera… - Msystems, 2022 - Am Soc Microbiol
Phages and prophages are one of the principal modulators of microbial populations.
However, much of their diversity is still poorly understood. Here, we extracted 33,624 …
However, much of their diversity is still poorly understood. Here, we extracted 33,624 …
DBSCAN-SWA: an integrated tool for rapid prophage detection and annotation
R Gan, FX Zhou, Y Si, H Yang, C Chen, C Ren… - Frontiers in …, 2022 - frontiersin.org
As an intracellular form of a bacteriophage in the bacterial host genome, a prophage usually
integrates into bacterial DNA with high specificity and contributes to horizontal gene transfer …
integrates into bacterial DNA with high specificity and contributes to horizontal gene transfer …
DEPhT: a novel approach for efficient prophage discovery and precise extraction
CH Gauthier, L Abad, AK Venbakkam… - Nucleic Acids …, 2022 - academic.oup.com
Advances in genome sequencing have produced hundreds of thousands of bacterial
genome sequences, many of which have integrated prophages derived from temperate …
genome sequences, many of which have integrated prophages derived from temperate …
PhageWeb–Web interface for rapid identification and characterization of prophages in bacterial genomes
AL Sousa, D Maués, A Lobato, EF Franco… - Frontiers in …, 2018 - frontiersin.org
This study developed a computational tool with a graphical interface and a web-service that
allows the identification of phage regions through homology search and gene clustering. It …
allows the identification of phage regions through homology search and gene clustering. It …
Phage hunters: Computational strategies for finding phages in large-scale 'omics datasets
A plethora of tools exist for identifying phage sequences in bacterial genomes, single cell
amplified genomes, and host-associated and environmental metagenomes. Yet because the …
amplified genomes, and host-associated and environmental metagenomes. Yet because the …
Phigaro: high-throughput prophage sequence annotation
EV Starikova, PO Tikhonova, NA Prianichnikov… - …, 2020 - academic.oup.com
Phigaro is a standalone command-line application that is able to detect prophage regions
taking raw genome and metagenome assemblies as an input. It also produces dynamic …
taking raw genome and metagenome assemblies as an input. It also produces dynamic …
Prophage genomics reveals patterns in phage genome organization and replication
Temperate phage genomes are highly variable mosaic collections of genes that infect a
bacterial host, integrate into the host's genome or replicate as low copy number plasmids …
bacterial host, integrate into the host's genome or replicate as low copy number plasmids …