Nebivolol: A Highly Selective β1‐Adrenergic Receptor Blocker That Causes Vasodilation by Increasing Nitric Oxide

S Gupta, HM Wright - Cardiovascular therapeutics, 2008 - Wiley Online Library
Nebivolol (Bystolic®) is a cardioselective beta 1 (β1)‐adrenergic receptor blocker with
endothelium‐dependent vasodilating properties. The endothelium‐dependent relaxation …

Nebivolol: An Endothelium-Friendly Selective β: 1:-Adrenoceptor Blocker

Y Gao, PM Vanhoutte - Journal of Cardiovascular Pharmacology, 2012 - journals.lww.com
Nebivolol is a highly selective β 1-adrenoceptor blocker, which also stimulates endothelial
nitric oxide synthase and scavenges reactive oxygen species (ROS). These characteristics …

Nebivolol: a novel beta-blocker with nitric oxide-induced vasodilatation

R Weiss - Vascular health and Risk management, 2006 - Taylor & Francis
Nebivolol is a novel beta1-blocker with a greater degree of selectivity for beta1-adrenergic
receptors than other agents in this class and a nitric oxide (NO)-potentiating, vasodilatory …

Nebivolol: Haemodynamic effects and clinical significance of combined β-blockade and nitric oxide release

O Kamp, M Metra, S Bugatti, L Bettari, A Dei Cas… - Drugs, 2010 - Springer
Nebivolol is a third-generation β-adrenergic receptor antagonist (β-blocker) with high
selectivity for β 1-adrenergic receptors. In addition, it causes vasodilatation via interaction …

Nitric oxide mechanisms of nebivolol

A Maffei, G Lembo - Therapeutic advances in cardiovascular …, 2009 - journals.sagepub.com
β-blockers are among the most widely used drugs in the prevention and treatment of
cardiovascular disease, although they are associated with increased peripheral resistance …

Experimental evidences of nitric oxide‐dependent vasodilatory activity of nebivolol, a third‐generation β‐blocker

L Ignarro - Blood Pressure, 2004 - Taylor & Francis
Nebivolol is a new and selective β 1‐adrenergic receptor antagonist whose haemodynamic
profile is different from that of classical β‐blockers. The blood pressure lowering effects of …

Nebivolol: the somewhat-different β-adrenergic receptor blocker

T Münzel, T Gori - Journal of the American College of Cardiology, 2009 - jacc.org
Although its clinical use in Europe dates almost 10 years, nebivolol is a β-blocker that has
been only recently introduced in the US market. Like carvedilol, nebivolol belongs to the …

[HTML][HTML] Nebivolol: vasodilator properties and evidence for relevance in treatment of cardiovascular disease

JG Howlett - Canadian Journal of Cardiology, 2014 - Elsevier
Abstract β-adrenergic blocking agents, a pharmacologically diverse class of cardiovascular
medications, are recommended as first-line treatment for patients with hypertension and …

Nebivolol: a review

J Cockcroft - Expert opinion on pharmacotherapy, 2004 - Taylor & Francis
Nebivolol is a vasodilating β-blocker, which can be distinguished from other β-blockers by its
haemodynamic profile. It combines β-adrenergic blocking activity with a vasodilating effect …

Clinical pharmacodynamics of nebivolol: new evidence of nitric oxide‐mediated vasodilating activity and peculiar haemodynamic properties in hypertensive patients

A Zanchetti - Blood pressure, 2004 - Taylor & Francis
New evidence from recently completed clinical studies performed with nebivolol, a highly
selective beta‐1 β‐blocker, endowed with additional vasodilating activity mediated by nitric …