The Na+, K+-ATPase maintains electrochemical gradients for Na+ and K+ that are critical for
animal cells. Cardiotonic steroids (CTSs), widely used in the clinic and recently assigned a …

The Na+, K+-ATPase belongs to the P-ATPase family, whose characteristic property is the
formation of a phosphorylated intermediate. The enzyme is also a defined target for …

The sodium pump (Na+, K+-ATPase, NKA) is vital for animal cells, as it actively maintains
Na+ and K+ electrochemical gradients across the cell membrane. It is a target of cardiotonic …

Cardiotonic steroids (CTSs) are specific and potent inhibitors of the Na+, K+-ATPase, with
highest affinity to the phosphoenzyme (E2P) forms. CTSs are comprised of a steroid core …

The focus of this article is on progress in establishing structure–function relationships
through site-directed mutagenesis and direct binding assay of Tl+, Rb+, K+, Na+, Mg2+ or …

The Na, K-ATPase is the membrane “pump” that generates the Na+ and K+ gradients across
the plasma membrane that drives many physiological processes. This enzyme is highly …

The Na+/K+ ATPase is an almost ubiquitous integral membrane protein within the animal
kingdom. It is also the selective target for cardiotonic derivatives, widely prescribed inhibitors …

The sodium-potassium pump (Na+, K+-ATPase) is responsible for establishing Na+ and K+
concentration gradients across the plasma membrane and therefore plays an essential role …

The Na, K-ATPase is specifically inhibited by cardiotonic steroids (CTSs) like digoxin and is
of significant therapeutic value in the treatment of congestive heart failure and arrhythmia …

The Na+-K+-ATPase (NKA) differs from most other ion transporters, not only in its capacity to
maintain a steep electrochemical gradient across the plasma membrane, but also as a …