The aim of this study was to investigate Parkinson's disease (PD) using a murine model of
PD. Specifically, we aimed to explore the mechanism by which puerarin prevents …

It has been acknowledged that oxidative stress, resulting in the apoptosis of dopaminergic
neurons, is a key mechanism in the pathogenesis of Parkinson's disease (PD). Puerarin …

Background Parkinson's disease (PD) is caused by the gradual loss of dopamine-producing
cells in the brain. This study evaluated the potential neuroprotective role of puerarin (PR) on …

Background Parkinson's disease (PD) is manifested as degeneration of dopaminergic
neurons in substantia nigra compacta. The mitochondrial dysfunction induced by oxidative …

Puerarin, a monomer of traditional Chinese medicine, is a key component of Pueraria radix.
Both clinical and experimental researches demonstrated that puerarin has therapeutic …

Neurodegeneration is one of the primary etiologies in the onset of Parkinson's disease. In
the quest for a new antiparkinsonism treatment the potential benefits of puerarin from the …

Tumor necrosis factor-α (TNF-α), a potential proinflammatory cytokine, is an important
component involved in neuronal apoptosis associated with neuroinflammation in the central …

In the previous report (Sonia Angeline et al., 2012), we showed an altered expression of
protective proteins in rotenone-induced Parkinson's disease (PD)-like rat model. This model …

Puerarin (Pur), an isoflavonoid extracted from the dried roots of Pueraria lobata, has been
reported to be useful in the treatment of various diseases. This study was designed to …

Objective: Fasudil, a Rho kinase inhibitor, has neuroprotection in the 1-methyl-4-phenyl-1, 2,
3, 6-tetrahydropyridine (MPTP)-based Parkinson's disease (PD). This study aims to …