Intravitreal injections are clinically established procedures in the treatment of posterior eye
diseases, such as wet age-related macular degeneration (wet AMD) which requires monthly …

Purpose: To characterize a biodegradable microsphere-hydrogel drug delivery system
(DDS) for controlled and extended release of ranibizumab. Methods: The degradable …

In this paper, a fast forming nano-composite hydrogel was developed for potential
application in ocular drug delivery. The optical transmission (OT) as well as rheological …

Background The distinct anatomy and physiology of the eye represent it as a specialized
organ. The noumenal physiological barriers, whose prominent role is to prevent the …

Development of an efficient intraocular drug delivery nanosystem remains the most difficult
challenge to attain a prolonged therapeutic effect at the site of drug action. The purpose of …

Ocular drug delivery has been a major challenge for clinical pharmacologists and
biomaterial scientists due to intricate and unique anatomical and physiological barriers in …

Hyaluronic acid (HA) is a widely investigated biomaterial for many therapeutic applications
owing to its unique properties of biocompatibility, biodegradation, and viscoelasticity. HA …

Bevacizumab, a vascular endothelial growth factor (VEGF)-targeting drug, is widely used as
an off-label therapeutic for age-related macular degeneration (AMD). To reduce the monthly …

Ophtalmic drug therapy remains to be a major pharmaceutical challenge due to the
presence of ocular barriers. The development of novel ophthalmic delivery systems is an …

The delivery of drugs to different parts of the eye through conventional approaches has been
a troublesome task for years, and the urge to overcome the disadvantages of these …