P2Y12 inhibition in high bleeding risk patients: making the right decision in a complex setting

K Dimitriadis, N Pyrpyris, K Aznaouridis… - European Heart …, 2023 - academic.oup.com
We read with great interest the SWEDEHEART report by Tjerkaski et al. 1 regarding the
comparison of ticagrelor vs. clopidogrel in patients with myocardial infarction (MI) and high …

Antiplatelet therapy aims and strategies in Asian patients with acute coronary syndrome or stable coronary artery disease

CC Tam, HF Tse - Journal of Clinical Medicine, 2022 - mdpi.com
Dual antiplatelet therapy (DAPT) has been the mainstay treatment to reduce ischemic
events, such as myocardial infarction or stroke, in patients with coronary artery disease …

[引用][C] P2Y12 Antagonists: pharmacology, efficacy and patient considerations

R Shameem, MS Hamid, A Randhawa, C Spaccavento… - Journal of Cardiovascular …, 2014

Safety and efficacy of different P2Y12 inhibitors in patients with acute coronary syndromes stratified by the PRAISE risk score: a multicentre study

G Patti, F D'Ascenzo, O De Filippo… - … Journal-Quality of …, 2022 - academic.oup.com
Aims To establish the safety and efficacy of different dual antiplatelet therapy (DAPT)
combinations in patients with acute coronary syndrome (ACS) according to their baseline …

Guided and unguided de-escalation from potent P2Y12 inhibitors among patients with acute coronary syndrome: a meta-analysis

AH Tavenier, R Mehran, M Chiarito… - European Heart …, 2022 - academic.oup.com
Aim Optimal dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary
intervention (PCI) for acute coronary syndrome (ACS) intends to balance ischemic and …

Impact of P2Y12 inhibitory effects induced by clopidogrel on platelet procoagulant activity in type 2 diabetes mellitus patients

DJ Angiolillo, P Capranzano, B Desai… - Thrombosis research, 2009 - Elsevier
INTRODUCTION: Type 2 diabetes mellitus (T2DM) patients have a variable response profile
to the P2Y12 receptor antagonist clopidogrel. P2Y12 receptor signalling promotes platelet …

Dual-pathway inhibition for secondary and tertiary antithrombotic prevention in cardiovascular disease

D Capodanno, DL Bhatt, JW Eikelboom… - Nature Reviews …, 2020 - nature.com
Advances in antiplatelet therapies for patients with cardiovascular disease have improved
patient outcomes over time, but the challenge of balancing the risks of ischaemia and …

Platelet inhibition agents: current and future P2Y12 receptor antagonists

J Tang, MP Li, HH Zhou… - Current Vascular …, 2015 - ingentaconnect.com
Percutaneous coronary intervention is widely used to reduce the risk of death or
cardiovascular events in patients with acute coronary syndromes. Dual antiplatelet treatment …

Comparison of pharmacodynamic effects of ticagrelor vs prasugrel in type 2 diabetes mellitus patients with coronary heart disease

LL Shang, DD Guo, HY Zhao, AJ Quan… - Journal of clinical …, 2018 - Wiley Online Library
What is known and objective Patients with type 2 diabetes mellitus (T2DM) are at higher risk
of thrombotic complications. Studies have indicated that patients with T2DM have impaired …

Still a long way to the precision medicine of antiplatelet strategy after percutaneous coronary intervention

YH Jeong, Y Obayashi, H Song… - Circulation …, 2022 - Am Heart Assoc
Antiplatelet therapy is essential to reduce athero-thrombotic events in patients undergoing
percutaneous coronary intervention (PCI), but this strategy is inevitably associated with an …