Toll-like receptors (TLRs) play a central role in host defense by inducing inflammatory and
adaptive immune responses following infection. Drugs that target TLRs are of considerable …

The family of Toll-like receptors (TLRs) is receiving considerable attention as potential
regulators and controllers of the immune response through their ability to recognize …

Abstract Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is
involved in innate immunity and mediates inflammatory responses by recognizing …

Introduction: Toll-like receptors (TLRs) are a crucial part of the innate immunity and present
the first line of defense against pathogens. In humans, there are ten TLRs, with TLR3, 7, 8 …

Activation or inhibition of TLR4 by small molecules will provide in the next few years a new
generation of therapeutics. TLR4 stimulation (agonism) by high-affinity ligands mimicking …

The Toll-like receptor (TLR) family plays a fundamental role in host innate immunity by
mounting a rapid and potent inflammatory response to pathogen infection. TLRs recognize …

Toll‐like receptor 2 (TLR 2) antagonists are key therapeutic targets because they inhibit
several inflammatory diseases caused by surplus TLR 2 activation. In this study, we …

Toll-like receptors (TLRs) are key receptors for the activation of immune responses directed
against pathogens. Among the more than 10 identified TLRs, TLR4 is the most unique …

Stimulation of toll-like receptor 2 (TLR2) by bacterial lipoproteins induces fast non-specific
immune responses against pathogens followed by slow but specific adaptive immune …

The interaction of innate and adaptive immune responses is extremely complex and just
beginning to be understood in detail. The tendency for biomedical research to establish …