Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
C Soto, S Pritzkow - Nature neuroscience, 2018 - nature.com
A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …
Protein misfolding and neurodegeneration
C Soto, LD Estrada - Archives of neurology, 2008 - jamanetwork.com
A key molecular pathway implicated in diverse neurodegenerative diseases is the
misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence …
misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence …
Misfolded protein aggregates: mechanisms, structures and potential for disease transmission
I Moreno-Gonzalez, C Soto - Seminars in cell & developmental biology, 2011 - Elsevier
Some of the most prevalent human degenerative diseases appear as a result of the
misfolding and aggregation of proteins. Compelling evidence suggest that misfolded protein …
misfolding and aggregation of proteins. Compelling evidence suggest that misfolded protein …
Cell biology of prions and prionoids: a status report
A Aguzzi, AKK Lakkaraju - Trends in cell biology, 2016 - cell.com
The coalescence of proteins into highly ordered aggregates is a hallmark of protein
misfolding disorders (PMDs), which, when affecting the central nervous system, lead to …
misfolding disorders (PMDs), which, when affecting the central nervous system, lead to …
The two faces of protein misfolding: gain‐and loss‐of‐function in neurodegenerative diseases
KF Winklhofer, J Tatzelt, C Haass - The EMBO journal, 2008 - embopress.org
The etiologies of neurodegenerative diseases may be diverse; however, a common
pathological denominator is the formation of aberrant protein conformers and the occurrence …
pathological denominator is the formation of aberrant protein conformers and the occurrence …
From molecule to molecule and cell to cell: prion-like mechanisms in amyotrophic lateral sclerosis
Prions, self-proliferating infectious agents consisting of misfolded protein, are most often
associated with aggressive neurodegenerative diseases in animals and humans. Akin to the …
associated with aggressive neurodegenerative diseases in animals and humans. Akin to the …
Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders?
TA Bayer - European neuropsychopharmacology, 2015 - Elsevier
The current review covers proteinopathies an umbrella term for neurodegenerative
disorders that are characterized by the accumulation of specific proteins within neurons or in …
disorders that are characterized by the accumulation of specific proteins within neurons or in …
Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases
R Morales, LD Estrada, R Diaz-Espinoza… - Journal of …, 2010 - Soc Neuroscience
The central event in protein misfolding disorders (PMDs) is the accumulation of a misfolded
form of a naturally expressed protein. Despite the diversity of clinical symptoms associated …
form of a naturally expressed protein. Despite the diversity of clinical symptoms associated …
Sequestration of cellular interacting partners by protein aggregates: implication in a loss‐of‐function pathology
H Yang, HY Hu - The FEBS journal, 2016 - Wiley Online Library
Protein misfolding and aggregation are a hallmark of several neurodegenerative diseases
(ND s). However, how protein aggregation leads to cytotoxicity and neurodegeneration is …
(ND s). However, how protein aggregation leads to cytotoxicity and neurodegeneration is …
Protein aggregate spreading in neurodegenerative diseases: problems and perspectives
Progressive accumulation of specific protein aggregates is a defining feature of many major
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, fronto …
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, fronto …
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