A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

A key molecular pathway implicated in diverse neurodegenerative diseases is the
misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence …

Some of the most prevalent human degenerative diseases appear as a result of the
misfolding and aggregation of proteins. Compelling evidence suggest that misfolded protein …

The coalescence of proteins into highly ordered aggregates is a hallmark of protein
misfolding disorders (PMDs), which, when affecting the central nervous system, lead to …

The etiologies of neurodegenerative diseases may be diverse; however, a common
pathological denominator is the formation of aberrant protein conformers and the occurrence …

Prions, self-proliferating infectious agents consisting of misfolded protein, are most often
associated with aggressive neurodegenerative diseases in animals and humans. Akin to the …

The current review covers proteinopathies an umbrella term for neurodegenerative
disorders that are characterized by the accumulation of specific proteins within neurons or in …

The central event in protein misfolding disorders (PMDs) is the accumulation of a misfolded
form of a naturally expressed protein. Despite the diversity of clinical symptoms associated …

Protein misfolding and aggregation are a hallmark of several neurodegenerative diseases
(ND s). However, how protein aggregation leads to cytotoxicity and neurodegeneration is …

Progressive accumulation of specific protein aggregates is a defining feature of many major
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, fronto …