Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

JC Barrett, S Hansoul, DL Nicolae, JH Cho, RH Duerr… - Nature …, 2008 - nature.com
Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

A Franke, T Balschun, TH Karlsen, J Hedderich… - Nature …, 2008 - nature.com
Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we
investigated 50 previously reported susceptibility loci in a German sample of individuals with …

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

A Franke, DPB McGovern, JC Barrett, K Wang… - Nature …, 2010 - nature.com
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …

Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

JV Raelson, RD Little, A Ruether… - Proceedings of the …, 2007 - National Acad Sciences
Genome-wide association (GWA) studies offer a powerful unbiased method for the
identification of multiple susceptibility genes for complex diseases. Here we report the …

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

MA Rivas, M Beaudoin, A Gardet, C Stevens… - Nature …, 2011 - nature.com
More than 1,000 susceptibility loci have been identified through genome-wide association
studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of …

Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease

K Wang, H Zhang, S Kugathasan, V Annese… - The American Journal of …, 2009 - cell.com
Previous genome-wide association (GWA) studies typically focus on single-locus analysis,
which may not have the power to detect the majority of genuinely associated loci. Here, we …

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

Y Momozawa, M Mni, K Nakamura, W Coppieters… - Nature …, 2011 - nature.com
Genome-wide association studies (GWAS) have identified dozens of risk loci for many
complex disorders, including Crohn's disease,. However, common disease-associated …

Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4

C Libioulle, E Louis, S Hansoul, C Sandor… - PLoS …, 2007 - journals.plos.org
To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide
association study with more than 300,000 SNPs characterized in 547 patients and 928 …

Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci

D Ellinghaus, E Ellinghaus, RP Nair, PE Stuart… - The American Journal of …, 2012 - cell.com
Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically,
pathologically, and therapeutically connected, but little is known about their shared genetic …

A genome-wide association study identifies 2 susceptibility loci for Crohn's disease in a Japanese population

K Yamazaki, J Umeno, A Takahashi, A Hirano… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Crohn's disease is an inflammatory bowel disease induced by
multiple genetic and environmental factors. Genome-wide association studies have …