Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment
B Bao, S Ali, A Ahmad, AS Azmi, Y Li, S Banerjee… - PloS one, 2012 - journals.plos.org
Hypoxia is known to play critical roles in cell survival, angiogenesis, tumor invasion, and
metastasis. Hypoxia mediated over-expression of hypoxia-inducible factor (HIF) has been …
metastasis. Hypoxia mediated over-expression of hypoxia-inducible factor (HIF) has been …
Hypoxia induced aggressiveness of prostate cancer cells is linked with deregulated expression of VEGF, IL-6 and miRNAs that are attenuated by CDF
B Bao, A Ahmad, D Kong, S Ali, AS Azmi, Y Li… - 2012 - journals.plos.org
Tumor hypoxia with deregulated expression of hypoxia inducing factor (HIF) and its
biological consequence leads to poor prognosis of patients diagnosed with solid tumors …
biological consequence leads to poor prognosis of patients diagnosed with solid tumors …
Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells
O Hashimoto, K Shimizu, S Semba, S Chiba, Y Ku… - Pathobiology, 2011 - karger.com
Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …
Effects of the HIF-1α and NF-κB loop on epithelial‑mesenchymal transition and chemoresistance induced by hypoxia in pancreatic cancer cells
ZX Cheng, DW Wang, T Liu, WX Liu… - Oncology …, 2014 - spandidos-publications.com
Hypoxia is a microenvironmental factor which plays a critical role in tumor development and
chemoresistance. Epithelial-to-mesenchymal transition (EMT) induced by hypoxia is one of …
chemoresistance. Epithelial-to-mesenchymal transition (EMT) induced by hypoxia is one of …
Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer
Q Zhang, Y Lou, J Zhang, Q Fu, T Wei, X Sun, Q Chen… - Molecular cancer, 2017 - Springer
Background Pancreatic cancer is a devastating disease that is characterized by persistent
hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α …
hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α …
Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer
Pancreatic tumors are renowned for their extremely hypoxic centers, resulting in
upregulation of a number of hypoxia mediated signaling pathways including cell …
upregulation of a number of hypoxia mediated signaling pathways including cell …
Hypoxia induces immunosuppression, metastasis and drug resistance in pancreatic cancers
H Zhang, K Cao, J Xiang, M Zhang, M Zhu, Q Xi - Cancer Letters, 2023 - Elsevier
Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a
majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional …
majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional …
Hypoxia: Friend or Foe for drug delivery in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors with
an overall five-year survival rate of that has only just reached 10%. The tumor …
an overall five-year survival rate of that has only just reached 10%. The tumor …
The impact of hypoxia in pancreatic cancer invasion and metastasis
A Yuen, B Díaz - Hypoxia, 2014 - Taylor & Francis
Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer
biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but …
biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but …