Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast

S Mehta, H Li, PG Hogan… - Molecular and cellular …, 2009 - Am Soc Microbiol
Regulators of calcineurin (RCANs) in fungi and mammals have been shown to stimulate and
inhibit calcineurin signaling in vivo through direct interactions with the catalytic subunit of the …

MoCRZ1, a gene encoding a calcineurin-responsive transcription factor, regulates fungal growth and pathogenicity of Magnaporthe oryzae

J Choi, Y Kim, S Kim, J Park, YH Lee - Fungal Genetics and Biology, 2009 - Elsevier
Ca2+-dependent signaling plays important roles in cellular development and metabolism in
fungi. Pharmacological and molecular evidence clearly indicates that Ca2+-dependent …

Calcineurin as a multifunctional regulator: unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis

PR Juvvadi, F Lamoth, WJ Steinbach - Fungal biology reviews, 2014 - Elsevier
Calcineurin signaling plays diverse roles in fungi in regulating stress responses,
morphogenesis and pathogenesis. Although calcineurin signaling is conserved among …

Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans

WH Jung, YE Son, SH Oh, C Fu, HS Kim… - G3: Genes …, 2018 - academic.oup.com
Calcineurin modulates environmental stress survival and virulence of the human fungal
pathogen Cryptococcus neoformans. Previously, we identified 44 putative calcineurin …

Drafting Penicillium oxalicum calcineurin-CrzA pathway by combining the analysis of phenotype, transcriptome, and endogenous protein–protein interactions

K Zhao, Z Liu, M Li, Y Hu, L Yang, X Song… - Fungal Genetics and …, 2022 - Elsevier
Fungi sense environmental signals and coordinate growth, development, and metabolism
accordingly. Calcium-calmodulin-calcineurin signaling is a conserved cascade pathway in …

Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae

DP Matheos, TJ Kingsbury, US Ahsan… - Genes & …, 1997 - genesdev.cshlp.org
Ca2+ signals regulate gene expression in animal and yeast cells through mechanisms
involving calcineurin, a protein phosphatase activated by binding Ca2+ and calmodulin …

Transcriptional expression of PHR2 is positively controlled by the calcium signaling transcription factor Crz1 through its binding motif in the promoter

L Jiang, H Xu, M Wei, Y Gu, H Yan, L Pan… - Microbiology …, 2024 - Am Soc Microbiol
ABSTRACT GH72 family of β-(1, 3)-glucanosyltransferases is required for cell wall
biogenesis, morphogenesis, and virulence of fungi. Candida albicans PHR2 is an acidic pH …

Regulation of Salt Tolerance by Torulaspora delbrueckii Calcineurin Target Crz1p

MJ Hernandez-Lopez, J Panadero, JA Prieto… - Eukaryotic …, 2006 - Am Soc Microbiol
Recently, the academic interest in the yeast Torulaspora delbrueckii has increased notably
due to its high resistance to several types of stress, including salt and osmotic imbalance …

Coping with stress: calmodulin and calcineurin in model and pathogenic fungi

PR Kraus, J Heitman - Biochemical and biophysical research …, 2003 - Elsevier
Calcium signaling via calmodulin and calcineurin is critical for the regulation of stress
responses in fungi. The functions of calmodulin and calcineurin are largely conserved …

The transcription factor FgCrz1A is essential for fungal development, virulence, deoxynivalenol biosynthesis and stress responses in Fusarium graminearum

L Chen, Q Tong, C Zhang, K Ding - Current genetics, 2019 - Springer
The zinc finger transcription factor Crz1 is an important downstream regulator of calcium-
dependent signal transduction pathways in many organisms. The function of Crz1 in the …