Progressive myocardial fibrosis, including the accumulation of collagen within the adventitia
of intramyocardial coronary arteries, is seen in the hypertrophied rat myocardium secondary …

Pathological left ventricular hypertrophy in renovascular hypertension is associated with the
accumulation of fibrillar collagen within the extracellular space and around intramyocardial …

An abnormal elevation in collagen concentration or myocardial fibrosis occurs in the
hypertrophied left ventricle of the rat with renovascular hypertension (RHT). The structural …

Objective: Myocardial fibrosis is an important determinant of pathological hypertrophy. In two
experimental models of arterial hypertension the purpose of the study was (a) to determine …

The myocardium contains collagen matrix that is a major determinant of its architecture,
structural integrity, and mechanical properties. This fibrillar matrix consists primarily of type I …

The interstitial space of the myocardium is composed of nonmyocyte cells and a highly
organized collagen network which serves to maintain the architecture and mechanical …

Activation of the renin-angiotensin-aldosterone system in arterial hypertension can lead to
remodeling of the myocardial collagen network, with progressive collagen accumulation in …

In both men and women left ventricular hypertrophy (LVH) is the major risk factor associated
with the appearance of diastolic and/or systolic myocardial failure. It is not the growth of …

Objective: To evaluate regression of experimental left ventricular hypertrophy (LVH) in terms
of its effects both on myocardial collagen levels and on diastolic stiffness. Methods: Two …

The cardiac interstitium is composed of non-myocyte cells embedded in a highly organized
extracellular matrix containing a three-dimensional collagen network which serves to …