Background and Purpose: In experimental arterial hypertension, left ventricular hypertrophy
(LVH) becomes pathologic with impaired myocardial function if myocardial fibrosis occurs …

Objectives: Diastolic dysfunction that determines symptoms and prognosis in patients with
systolic dysfunction causes heart failure even in the absence of systolic dysfunction. Our …

Background Fibrosis is commonly found in association with cardiac hypertrophy and failure,
but the relation of the connective tissue response to the development of impaired cardiac …

Myocardial fibrosis can be defined as an abnormal increase in collagen concentration of
either ventricle. This accumulation of collagen, represented predominantly by fibrillar type I …

Left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHR) is
accompanied by a structural remodeling of the myocardium that includes myocyte …

In hypertensive heart disease, reactive myocardial fibrosis represents as an excessive
accumulation of fibrillar collagen within the normal connective tissue structures of the …

The effect of long-term administration of delapril, an angiotensin converting enzyme
inhibitor, and candesartan, an angiotensin II receptor blocker, on cardiac hypertrophy was …

Cardiac fibrosis is one of the deleterious events accompanying hypertension that may be
implicated in the progression toward heart failure. To determine the mechanisms involved in …

The interaction of the renin-angiotensin-aldosterone system (RAAS) and cardiac growth is of
great interest in chronic heart failure. The pressure or volume overloaded heart shows a …

The major risk factor associated with the appearance of adverse cardiovascular events and
outcome attributable to cardiovascular disease is left ventricular hypertrophy (LVH). Why this …