This study had two objectives:(a) to determine the accumulation of collagen and its structural
remodelling in the hypertrophied rat left ventricle after 4 and 8 weeks of abdominal aorta …

Sustained increase in arterial pressure causes left ventricular hypertrophy and adversely
affects all myocardial compartments: myocytes, interstitium, and coronary vasculature …

In genetic and acquired hypertension, a structural remodeling of the nonmyocyte
compartment of myocardium, including the accumulation of fibrillar collagen and other …

To determine the molecular events responsible for the disproportionate accumulation of
myocardial fibrillar collagens during sustained hypertension, we examined the in vivo rate of …

1. The myocardial collagen matrix is an active participant in determining ventricular
architecture and diastolic function, and myocardial structural integrity and mechanical …

Extrahepatic synthesis and localization of angiotensinogen have been described in animals,
thus establishing the tissue, renin-angiotensin system. We examined angiotensinogen …

Chronic hypertension, known to affect the collagen profile of the heart, and exercise result in
impaired or improved heart function, respectively. Collagen types I [alpha 1 (I) 2 and alpha 2 …

The spontaneously hypertensive rat (SHR) exhibits a transition from stable compensated left
ventricular (LV) hypertrophy to heart failure (HF) at a mean age of 21 months that is …

In this report we review the replacement (ie, scarring) and reactive (ie, perivascular and
interstitial fibrosis) fibrous tissue responses found in the myocardium in response to effector …

In chronic heart failure, the inter-relationship of the renin-angiotensin-aldosterone system
(RAAS) and cardiac growth is of primary clinical interest. In the pressure or volume …