To evaluate the effects of hypertension on cardiac hypertrophy, on myocardial structure, and
on ventricular arrhythmias, 27 3-month-old spontaneously hypertensive rats were treated …

Patients with chronic congestive heart failure manifest≥ 1 of the following abnormalities:
diastolic dysfunction, systolic dysfunction, and arrhythmias. Diastolic dysfunction, one of the …

Light and electron microscopic stereological studies were performed on the myocardium of
spontaneously hypertensive rats (SHR-SP) before and after treatment with nif edipine (27 …

Angiotensin-converting enzyme (ACE) is present in tissues composed largely of fibrillar
collagen such as heart valves, the adventitia of great vessels and intramyocardial coronary …

Aldosterone has been considered a key hormone in the regulation of water, sodium and
potassium metabolism, thus influencing blood pressure regulation. More recently, several …

The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure
overload-induced left ventricular (LV) hypertrophy were studied in female Sprague–Dawley …

In this study we report the changes of interstitial collagen in the human non-infarcted
interventricular septum after a myocardial infarction as well as in hypertrophic human hearts …

To determine whether chronic antihypertensive therapy prevents the progression of cardiac
hypertrophy and the deterioration in cardiac performance observed in spontaneously …

The development of hypertension is accompanied by rarefaction of arterioles and capillaries
in both animal models and humans. Although many studies have examined the effects of …

A perivascular fibrosis of intramyocardial coronary arterioles, composed of type I fibrillar
collagen, is associated with chronic elevations in circulating angiotensin II (AngII). The …