The development of hypertension is accompanied by rarefaction of arterioles and capillaries
in both animal models and humans. Although many studies have examined the effects of …

A collagen network, composed largely of type I and III fibrillar collagens, is found in the
extracellular space of the myocardium. This network has multiple functions which includes a …

The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure
overload-induced left ventricular (LV) hypertrophy were studied in female Sprague–Dawley …

In this study we report the changes of interstitial collagen in the human non-infarcted
interventricular septum after a myocardial infarction as well as in hypertrophic human hearts …

Chronic administration of either angiotensin II (Ang II) or aldosterone (ALDO) leads to
myocardial fibrosis. Myofibroblasts (myoFb) play a major role in collagen accumulation at …

To determine whether chronic antihypertensive therapy prevents the progression of cardiac
hypertrophy and the deterioration in cardiac performance observed in spontaneously …

A perivascular fibrosis of intramyocardial coronary arterioles, composed of type I fibrillar
collagen, is associated with chronic elevations in circulating angiotensin II (AngII). The …

Objective: Chronic elevations in plasma angiotensin II (AngII) are associated with an efflux of
plasma macromolecules into the perivascular and contiguous interstitial space. This is …

In this study we infused phenylephrine into adult Wistar rats and used losartan to test for a
possible role of angiotensin II in the phenylephrine-induced fibrosis. Phenylephrine, given …

In essential hypertension, ventricular function is determined primarily by the degree of
hypertrophy (myocardial factor) and by the organic complications in the coronary artery …