Noncollagenous proteins regulate the formation of the mineral constituent in hard tissue.
The mineral formed contains apatite crystals coated by a functional disordered calcium …

Mineralization of fibrillar collagen with biomimetic process-directing agents has enabled
scientists to gain insight into the potential mechanisms involved in intrafibrillar …

The polymeric matrix of mineralized tissues controls the form and structure of the mineral
that is deposited. This matrix has an insoluble fraction which provides a structural framework …

Physiologic mineralization is necessary for the formation of skeletal tissues and for their
appropriate functions during adulthood. Mineralization has to be controlled and restricted to …

Bone biomineralization is a complex process in which type I collagen and associated non-
collagenous proteins (NCPs), including glycoproteins and proteoglycans, interact closely …

Bone formation and development is a dynamic process involving a series of precisely
controlled, distinct, cellular, and biochemical events. As bone matures, stage-specific bone …

Biomineralized scaffolds are an attractive option for bone tissue engineering, being similar
to native bone. However, optimization is difficult, due to the complex interplay among …

The critical role of the self-assembled structure of collagen in skeletal mineralization is long
recognized, yet the angstrom to tens of nanometers length-scale nucleation mechanism of …

Biomineralization processes govern the formation of hierarchical hard tissues such as bone
and teeth in living organisms, and mimicking these processes could lead to the design of …