Respiration supports intraphagosomal filamentation and escape of Candida albicans from macrophages

NT Case, J Westman, MT Hallett, J Plumb, A Farheen… - Mbio, 2023 - Am Soc Microbiol
For the human fungal pathogen Candida albicans, metabolic flexibility and the ability to
transition between yeast and filamentous growth states are key virulence traits that enable …

Mechanism of Candida pathogenesis: revisiting the vital drivers

IE Mba, EI Nweze - European Journal of Clinical Microbiology & Infectious …, 2020 - Springer
Candida is the most implicated fungal pathogen in the clinical setting. Several factors play
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …

The two-component signal transduction system and its regulation in Candida albicans

B Liao, X Ye, X Chen, Y Zhou, L Cheng, X Zhou, B Ren - Virulence, 2021 - Taylor & Francis
Candida albicans, which can cause superficial and life-threatening systemic infections, is
the most common opportunistic fungal pathogen in the human microbiome. The two …

Candida albicans actively modulates intracellular membrane trafficking in mouse macrophage phagosomes

E Fernández‐Arenas, CKE Bleck… - Cellular …, 2009 - Wiley Online Library
The intracellular trafficking/survival strategies of the opportunistic human pathogen Candida
albicans are poorly understood. Here we investigated the infection of RAW264. 7 …

Proteomic Analysis of Candida albicans Cell Walls Reveals Covalently Bound Carbohydrate-Active Enzymes and Adhesins

PWJ de Groot, AD de Boer, J Cunningham… - Eukaryotic …, 2004 - Am Soc Microbiol
Covalently linked cell wall proteins (CWPs) of the dimorphic fungus Candida albicans are
implicated in virulence. We have carried out a comprehensive proteomic analysis of the …

Transcriptional Response of Candida albicans upon Internalization by Macrophages

MC Lorenz, JA Bender, GR Fink - Eukaryotic cell, 2004 - Am Soc Microbiol
The opportunistic fungal pathogen Candida albicans is both a benign gut commensal and a
frequently fatal systemic pathogen. The interaction of C. albicans with the host's innate …

Identifying infection-associated genes of Candida albicans in the postgenomic era

D Wilson, S Thewes, K Zakikhany, C Fradin… - FEMS yeast …, 2009 - academic.oup.com
The human pathogenic yeast Candida albicans can cause an unusually broad range of
infections reflecting a remarkable potential to adapt to various microniches within the human …

Targeted Changes of the Cell Wall Proteome Influence Candida albicans Ability to Form Single- and Multi-strain Biofilms

V Cabral, S Znaidi, LA Walker, H Martin-Yken… - PLoS …, 2014 - journals.plos.org
Biofilm formation is an important virulence trait of the pathogenic yeast Candida albicans.
We have combined gene overexpression, strain barcoding and microarray profiling to …

Recent advances in yeast organelle and membrane proteomics

T Premsler, RP Zahedi, U Lewandrowski… - …, 2009 - Wiley Online Library
Yeast proteome research comprises two different aspects: with respect to systemic fungal
infections (fungemias), invasive candidiasis, for instance by Candida albicans, is among the …

Infection-related gene expression in Candida albicans

AJP Brown, FC Odds, NAR Gow - Current opinion in microbiology, 2007 - Elsevier
Research into the major fungal pathogen, Candida albicans has firmly entered the post-
genomics era. The current challenge is to apply these technologies to the analysis of C …