Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity
TRPM2 is a Ca2+-permeable nonselective cation channel that plays important roles in
oxidative stress–mediated cell death and inflammation processes. However, how TRPM2 is …
oxidative stress–mediated cell death and inflammation processes. However, how TRPM2 is …
Roles of TRPM2 in oxidative stress
N Takahashi, D Kozai, R Kobayashi, M Ebert, Y Mori - Cell calcium, 2011 - Elsevier
Reactive oxygen species (ROS) play critical roles in cell death, diseases, and normal
cellular processes. TRPM2 is a member of transient receptor potential (TRP) protein …
cellular processes. TRPM2 is a member of transient receptor potential (TRP) protein …
State-dependent inhibition of TRPM2 channel by acidic pH
Transient receptor potential melastatin 2 (TRPM2) channel fulfills an important role in
oxidative stress signaling in immune and other cells, to which local extracellular acidosis is …
oxidative stress signaling in immune and other cells, to which local extracellular acidosis is …
The calcium‐permeable non‐selective cation channel TRPM2 is modulated by cellular acidification
JG Starkus, A Fleig, R Penner - The Journal of physiology, 2010 - Wiley Online Library
TRPM2 is a calcium‐permeable non‐selective cation channel expressed in the plasma
membrane and in lysosomes that is critically involved in aggravating reactive oxygen …
membrane and in lysosomes that is critically involved in aggravating reactive oxygen …
Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7
The channel kinases TRPM6 and TRPM7 have recently been discovered to play important
roles in Mg 2+ and Ca 2+ homeostasis, which is critical to both human health and cell …
roles in Mg 2+ and Ca 2+ homeostasis, which is critical to both human health and cell …
TRPM2 channel properties, functions and therapeutic potentials
Importance of the field: Oxidative stress, through production of reactive oxygen species,
triggers disturbance in intracellular calcium [Ca2+] i homeostasis, which has been identified …
triggers disturbance in intracellular calcium [Ca2+] i homeostasis, which has been identified …
TRPM2: a multifunctional ion channel for calcium signalling
A Sumoza‐Toledo, R Penner - The Journal of physiology, 2011 - Wiley Online Library
The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an
important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions …
important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions …
Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity
S Yamaguchi, A Tanimoto, K Otsuguro, H Hibino… - Journal of Biological …, 2014 - ASBMB
Transient receptor potential (TRP) channel melastatin subfamily member 4 (TRPM4) is a
broadly expressed nonselective monovalent cation channel. TRPM4 is activated by …
broadly expressed nonselective monovalent cation channel. TRPM4 is activated by …
A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death
TRPM2 is a Ca 2+-permeable channel that is activated by oxidative stress and confers
susceptibility to cell death. Here, an isoform of TRPM2 was identified in normal human bone …
susceptibility to cell death. Here, an isoform of TRPM2 was identified in normal human bone …