The effects of hypotonic (180 mOsm) and hypertonic (580 mOsm) medium loading on
chondrocyte aggrecan gene expression in 2D monolayer and 3D hydrogel culture (agarose …

Articular cartilage responds to its mechanical environment through altered cell metabolism
and matrix synthesis. In this study, isolated articular chondrocytes were cultured in collagen …

The aim of this study was to investigate the effect of hydrostatic pressure on the expression
of messenger ribonucleic acid (mRNA) for specific extracellular matrix proteins in …

The goal of this study was to examine the effects of mechanical compression on chondrocyte
biosynthesis of extracellular matrix (ECM) components during culture in a new alginate disk …

Static and dynamic compression are known to modulate the metabolism of articular
cartilage. The present study focused on determining the effects of compressive loading on …

Osteoarthritis (OA) develops as a consequence of articular cartilage degeneration possibly
initiated by excessive or abnormal loading of the joint, and potentially mediated through a …

This study analyzes the molecular response of articular chondrocytes to short-term
mechanical loading with a special focus on gene expression of molecules relevant for matrix …

Overcoming the limited ability of articular cartilage to self-repair may be possible through
tissue engineering. However, bioengineered cartilage formed using current methods does …

Background Articular cartilage is exposed to high mechanical loads under normal
physiological conditions and articular chondrocytes regulate the composition of …

The effects of compressive stress on the rate of proteoglycan synthesis and release were
determined in bovine articular cartilage from 4–5-month-old animals. Full depth cartilage …