OBJECTIVE: The objective of this study was to measure the effects of dynamic compression
on single chondrocyte gene expression using a single cell approach, combining single cell …

This paper describes the development and use of a direct compression stimulator for
culturing explants from the meniscus of the knee and articular cartilage. Following design …

Objective Traumatic joint injury can initiate early cartilage degeneration in the presence of
elevated inflammatory cytokines (eg, tumor necrosis factor (TNF)-α and interleukin (IL)-6) …

Objective To determine molecular events in the regulation of messenger RNA (mRNA) of
cartilage matrix molecules and proteases by mechanical stimulation of chondrocytes from …

Articular cartilage is recalcitrant to endogenous repair and regeneration and is thus a focus
of tissue engineering and regenerative medicine strategies. A prerequisite for articular …

Chondrogenesis in cartilage development and repair and cartilage degeneration in arthritis
can be regulated by mechanical-load-induced physical factors such as tissue deformation …

Articular cartilage is routinely subjected to mechanical forces and to cell‐regulatory
molecules. Previous studies have shown that mechanical stimuli can influence articular …

OBJECTIVE: Macromolecules of the articular cartilage extracellular matrix released into
synovial fluid, blood, or urine can serve as potentially useful biomarkers of the severity of …

The boundary lubrication function of articular cartilage is mediated in part by molecules at
the articular surface and in synovial fluid, encoded by Prg4. The objective of this study was …

In paired observations the in vitro proteoglycan turnover was studied of human normal and
osteoarthritic cartilage in the absence and presence of intermittent hydrostatic compressive …