The current therapy for human autoimmune disease is based on nonselective
immunosuppression achieved by corticosteroids or cytotoxic drugs. This form of therapy is …

The studies summarized in this chapter indicate that chronic bacterial, viral, and parasitic
infections can serve as a trigger factor of autoimmune reactivity according to various …

Autoimmune disease has long been considered a shadow following infectious diseases.
Epidemiological evidence shows that rheumatic fever follows streptococcal infection …

The last decade witnessed an explosion in information concerning the mechanisms
underlying the host's immune response to invading microorganisms, as well as during …

Autoimmune diseases are common diseases in which loss of tolerance within the immune
system results in pathologic immune responses that target either cellular or organ-specific …

The immune system of the host responds to foreign molecules while avoiding reactions
against molecules (self-antigens) of the host itself. This ability to discriminate self from …

One of the major questions in biology is, what are the initiating or inciting factors involved in
immune responses to self that lead to autoimmune disease? The answer would point to the …

Both genetic and environmental factors contribute to the development of autoimmunity.
Animals and humans exposed to natural infections have a reduced rate of autoimmune …

Highlights•Inborn errors of immunity include monogenic autoimmunity.•Immune
dysregulation in monogenic autoimmunity can alter pathogen defense.•Understanding …

Excitement has been high in the immunological community, as animal and human studies
have suggested that autoimmune diseases can be prevented or inhibited by treatment with …