ABSTRACT QPX7728 is a new ultrabroad-spectrum inhibitor of serine and metallo-beta-
lactamases (MBLs) from a class of cyclic boronates that gave rise to vaborbactam. The …

beta-Lactamases constitute the major defense mechanism of pathogenic bacteria against
beta-lactam antibiotics. When the beta-lactam ring of this antibiotic class is hydrolyzed …

ABSTRACT β-Lactamase-mediated resistance is a growing threat to the continued use of β-
lactam antibiotics. The use of the β-lactam-based serine-β-lactamase (SBL) inhibitors …

Since the discovery of penicillin by Alexander Fleming in 1929 as a therapeutic agent
against staphylococci, β-lactam antibiotics (BLAs) remained the most successful antibiotic …

ABSTRACT QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor, with
potent inhibition of key serine and metallo-beta-lactamases being observed in biochemical …

The use of β-lactamase inhibitors in combination with a β-lactamase-susceptible antibiotic is
a useful strategy to rescue otherwise good antibiotics from failure. However, recent years …

Novel β‐lactamase inhibitors have extended the reach of new and existing β‐lactams
against multidrug‐resistant bacteria expressing β‐lactamases. The efficacy of these …

The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

Avibactam is a non-β-lactam β-lactamase inhibitor with a spectrum of activity that includes β-
lactamase enzymes of classes A, C, and selected D examples. In this work acylation and …

Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in
part due to the presence of chromosomally encoded β-lactamases, including class C …