The β-lactamase cycle: a tale of selective pressure and bacterial ingenuity - Natural Product
Reports (RSC Publishing) DOI:10.1039/A705983C Royal Society of Chemistry View PDF …

Penicillin, the first of the β-lactam antibiotics, was introduced into medical practice in the
1940s. Since then, a large number of different β-lactams, including penicillins …

Despite 70 years of clinical use, β-lactam antibiotics still remain at the forefront of
antimicrobial chemotherapy. The major challenge to these life-saving therapeutics is the …

The β‐lactams—a large class of diverse compounds—due to their excellent safety profile
and broad antimicrobial spectrum are considered to be the most widely used therapeutic …

ABSTRACT β-Lactamase enzymes (EC 3.5. 2.6) are a significant threat to the continued use
of β-lactam antibiotics to treat infections. A novel non-β-lactam β-lactamase inhibitor with …

Since first reported in Europe in the early 1980s, extended-spectrum β-lactamases (ESBLs)
have spread worldwide. When producing these broad-spectrum plasmid-encoded enzymes …

Multidrug-resistant (MDR) bacterial infections are a serious threat to public health. Among
the most alarming resistance trends is the rapid rise in the number and diversity of β …

Extended-spectrum b-lactamases (ESBLs) are enzymes produced by gram-negative bacilli
that have the ability to inactivate b-lactam antibiotics containing an oxyimino group (ie …

A gradual rise in drug-resistant trends among Gram-negative organisms, especially
carbapenem-resistant (CR) Enterobacteriaceae (CRE), CR-Pseudomonas aeruginosa, and …

Although β-lactams have been the most effective class of antibacterial agents used in
clinical practice for the past half century, their effectiveness on Gram-negative bacteria has …