Background A hypoxic tumor microenvironment promotes the recruitment and transformation
of macrophages and facilitates tumor progression. Hypoxia-induced factor-1α (HIF-1α) is a …

The expression of hypoxia-induced factor (HIF)-1α is up-regulated in tumor
microenvironments under hypoxia condition. However, the prognostic significance of HIF-1α …

Background: Hypoxia was a common feature for accelerating tumor metastasis by both
inducting epithelial-mesenchymal transition (EMT) of tumor cells and polarization of tumor …

Esophageal cancer (EC) is a malignancy with poor prognosis and high mortality. Hypoxic
microenvironment has also been proved to be an important feature of tumors. Herein, we …

Objective To investigate the correlations among the expressions of hypoxia-inducible factor-
1α (HIF-1α), vascular endothelial cell growth factor (VEGF) and microvessel density (MVD) …

Background: In microenvironment of malignant tumors, Hypoxia-Inducible Factors (HIF),
most importantly HIF-1α, play an important role in regulation of adaptive biological response …

Hypoxia inducible factor 1α (HIF-1α) is highly expressed and is implicated in the progression
of esophageal squamous cell carcinoma. To investigate the potential mechanism by which …

Background. Esophageal cancer is one of the most lethal tumors worldwide. The most
common histological type in China is esophageal squamous cell carcinoma (ESCC) …

Objective To explore the expression of hypoxia inducible factor-1α (HIF-1α) in esophageal
squamous cell carcinoma and its correlation with clinicopathological features. Methods …

AIM: To investigate the effects of HIF-1α by RNAi on invasion and metastasis of esophageal
carcinoma Eca109 cells in vitro and in vivo, in order to explore its probable mechanism …