Background: Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer
deaths globally, in which hypoxia and activated hypoxia-inducible factors (HIFs) play an …

Abstract Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion
and metastasis, but no study has reported its action in esophageal carcinoma. The goal of …

The goal of this study was to explore the molecular mechanism of hypoxia inducible factor‐1
alpha (HIF‐1 alpha) action on migration and invasion of esophageal carcinoma cells. We …

Background: Tissue hypoxia is a characteristic of many human malignant neoplasms, and
hypoxia inducible factor-1 (HIF-1) plays a pivotal role in essential adaptive response to …

Tumor-associated macrophages (TAMs) constitute major infiltrates of solid tumors and
express a marker profile that characterizes alternatively activated macrophages (MФs) …

Abstract Hypoxia‑inducible‑factor 1α (HIF‑1α) is a marker for poor prognosis in the majority
of the cancer types, and it has been revealed to be essential for maintaining cancer stem …

In tumor tissues, tumor cells and tumor stromal cells interact with each other, generating the
complex tumor microenvironment (TME). Whereas cancer-associated fibroblasts (CAFs) are …

Oesophageal squamous cell carcinoma (ESCC) is a common type of carcinoma. Hypoxia is
associated with chemo‑and radio‑resistance, which may lead to a poor prognosis. Hypoxia …

Hypoxia inducible factor-1α (HIF-1α) and Wnt/β-catenin signal pathway has been reported to
be involved in tumor progression in various types of cancers. However, the molecular …

Low tissue oxygenation, termed hypoxia, is a characteristic of solid tumors with negative
consequences. Tumor-associated macrophages (TAMs) accumulate in hypoxic tumor …