Background Very little is known about the role inflammation and mechanism (s) that enables
the tumor to evade host's anti-tumor immune function during very initial days of tumor …

Background The transcriptional factor hypoxia-inducible factor 1α (HIF-1α) controls
angiogenesis and metabolism by upregulating hypoxia-induced genes, such as the vascular …

Abstract Purpose Tumor-associated macrophages (TAMs), are crucial for the survival and
development of tumor cells. Heat shock factor 1 (HSF1) is a potent, complex carcinogenesis …

Hypoxia plays a key role in tumour initiation and metastasis; one of the mechanisms is to
induce epithelial-mesenchymal transition (EMT). Signal transducer and activator of …

T cells can inhibit tumor growth, but their function in the tumor microenvironment is often
suppressed. Many solid tumors exhibit abundant macrophage infiltration and low oxygen …

Purpose: This study aimed to investigate the functional difference between hypoxia
inducible factor (HIF)-1α and HIF-2α in oral squamous cell carcinomas (OSCC) …

Background Hypoxia is a hallmark of the solid tumor microenvironment and is associated
with poor outcomes in cancer patients. The present study was performed to investigate …

The hypoxia-inducible transcription factors (HIF) 1α and HIF-2α play a critical role in cellular
response to hypoxia. Elevated HIF-α expression correlates with poor patient survival in a …

Simple Summary Gastric cancer is one of the most aggressive tumors in the clinic that is
resistant to chemotherapy. Gastric tumors are rich in hypoxic niches, and high expression of …