Human opiorphin QRFSR-peptide protects enkephalins from degradation by human neutral
endopeptidase (hNEP) and aminopeptidase-N (hAP-N) and inhibits pain perception in a …

Mammalian zinc ectopeptidases play important roles in turning off neural and hormonal
peptide signals at the cell surface, notably those processing sensory information. We report …

Human opiorphin protects enkephalins from degradation by human neutral endopeptidase
and aminopeptidase-N and inhibits pain perception in various behavioral rodent models of …

Like other endogenous enkephalinase inhibitors, human opiorphin peptide (QRFSR)
attenuates catabolism of enkephalins and appears to be a promising therapeutic, displaying …

Background Opiorphin is a naturally occurring potent analgesic human peptide. It protects
enkephalins from degradation and inhibits pain perception in various acute pain models via …

Background: Opiorphin is an endogenous human peptide regulator of enkephalin
bioavailability. It inhibits enkephalin-inactivating ectopeptidases to produce analgesia and …

Orphanin FQ (OFQ, also known as nociceptin) has been proposed to oppose the
antinociceptive effect of endogenous opioid peptides in the brain. We sought to determine …

RECENT studies that intracerebroventricular (icv) administration of orphanin FQ (OFQ)
blocks opioidinduced antinociception in a variety of animal models of pain. In the present …

In the present study, we investigated the effects of human opiorphin on colonic motility and
nociception in mice. In in vitro bioassay, opiorphin (10− 6 to 10− 4M) caused colonic …

Orphanin FQ (OFQ), the endogenous ligand for the orphan opioid receptor, LC132, was
recently isolated and characterized. The anti-opioid role of OFQ in supraspinal pain …