Objectives. To examine prevalence of low-and high-grade cervical lesions over time in a
large cohort of US female adolescents and women. Methods. We used health care claims …

BACKGROUND Cervical intraepithelial neoplasia grade 2, 3, and adenocarcinoma in situ
(CIN2+) lesions can be monitored as early indicators of human papillomavirus (HPV) …

Background Trends in human papillomavirus (HPV)–associated cervical lesions can provide
an indication of vaccine impact. Our purpose was to measure trends in cervical lesions …

Background: To date, the impact of the human papillomavirus (HPV) vaccine on invasive
cervical cancers in the United States has not been documented due, in part, to the time …

Vaccines that prevent infection with human papillomavirus (HPV) types 16 and 18 that are
known to cause cervical cancer have been available in the United States since 2006. High …

Background To understand real-world human papillomavirus (HPV) vaccine impact,
continuous evaluation using population-based data is critical. We evaluated the early impact …

Importance A substantial effect of human papillomavirus (HPV) vaccines on reducing HPV-
related cervical disease is essential before modifying clinical practice guidelines in partially …

The effectiveness of a vaccination program is influenced by its design and implementation
details and by the target population characteristics. Using routinely collected population …

The impact of human papillomavirus (HPV) vaccination on cervical screening, colposcopy,
and treatment is incompletely understood. In 2004–2005, investigators in the Costa Rica …

Background: The impact of human papillomavirus (HPV) vaccination has been observed in
the United States through declining cervical precancer incidence in young women. To …