Obesity and atherosclerosis are the most prevalent metabolic diseases. ApoE−/− and ob/ob
mice are widely used as models to study the pathogenesis of these diseases. However, how …

An imbalance of energy intake and expenditure is commonly considered as the fundamental
cause of obesity. However, individual variations in susceptibility to obesity do indeed exist in …

Obesity can be caused by microbes producing metabolites; it is thus important to determine
the correlation between gut microbes and metabolites. This study aimed to identify gut …

Background The incidence of obesity is increasing worldwide, and it is a risk factor for
diabetes, dyslipidemia, and nonalcoholic fatty liver disease. Our previous study had …

A combinatory approach using metabolomics and gut microbiome analysis techniques was
performed to unravel the nature and specificity of metabolic profiles related to gut ecology in …

The gut microbiota interacts with the host via production of various metabolites of dietary
nutrients. Herein, we proposed the concept of the gut microbiota-derived core nutrient …

Background Although the gut microbiota may be involved in obesity onset and progression,
the exact association of the gut microbiota in metabolically healthy obesity (MHO) remains …

Gut microbiota play important roles in host metabolism, especially in diabetes. However,
why different diets lead to similar diabetic states despite being associated with different …

Diet-based models are commonly used to investigate obesity and related disorders. We
conducted a comparative profiling of three obesogenic diets HFD, high fat diet; HFHF, high …

Objective To investigate the relationship between gut microbiota and the fecal metabolites of
hypoxic environments in mice. Methods High-fat diet-induced obese mice (n= 20) and …