A series of proline analogues of anthraquinone-2-carboxylic acid (1–3) were synthesized
and evaluated for cytotoxic activity in the cultured breast cancer MCF-7 cells. The …

As a continuous study we prepared several alkylamine (n= 3–6) and evaluated for the
pharmacological activity and mode of action. In the topoisomerase IIα (topo IIα) inhibition …

Abstract Evaluation of the cytotoxicity of novel octahydropyrazin [2, 1-a: 5, 4-a′]
diisoquinoline derivatives (1a–2c) employing a 3-(4, 5-dimethylthiazol-2-yl)-2, 5 …

We have designed and synthesized a series of 2, 4, 6-triaryl pyridine derivatives containing
chlorophenyl and phenolic moeity at 2-and 4-position of the central pyridine, respectively …

This work was undertaken to compare cytotoxicity, DNA damaging properties and effect on
DNA cleavage by topoisomerase II of the anthracycline drug doxorubicin (DOX) and its two …

Two anthraquinone derivatives of the anticancer drugs mitoxantrone and ametantrone were
examined for their ability to bind to DNA and to modulate the formation of topoisomerase …

Some 2-or 6-acyl-5, 8-dimethoxy-1, 4-naphthoquinone (DMNQ) derivatives were
synthesized and evaluated for inhibition of DNA topoisomerase I and cytotoxicity against …

A new series of 2-phenol-4-chlorophenyl-6-aryl pyridines were designed, synthesized, and
evaluated for topoisomerase (topo) I and II inhibitory activities as well as cytotoxic activity …

A new series of thirteen N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-
aspartic acid-β-benzyl ester compounds were synthesized and evaluated for antiproliferative …

Anthracenedione derivatives are widely used structures to target DNA in chemotherapy. One
of the major problem related to their use is their lack of sequence selectivity along the …