Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G+ C, Gram-
positive bacteria that have evolved a complex chemical language of natural product …

Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

Microorganisms have provided abundant sources of natural products which have been
developed as commercial products for human medicine, animal health, and plant crop …

Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

The actinomycetes are well-known bioactive natural product producers, comprising the
Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic …

Actinomycetes are well known as an inexhaustible source for antibiotics. Most of the known
antimicrobials today were originally isolated from actinomycetes, especially from the genus …

Natural products from microbes have provided humans with beneficial antibiotics for
millennia. However, a decline in the pace of antibiotic discovery exerts pressure on human …

Microbial natural products, particularly those produced by filamentous Actinobacteria,
underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic …

Genomic sequence data have revealed the presence of a large fraction of putatively silent
biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary …

Traditional natural product discovery methods have nearly exhausted the accessible
diversity of microbial chemicals, making new sources and techniques paramount in the …