APOE ε4 is the major genetic risk factor for sporadic Alzheimer's disease (AD). Although
APOE ε4 is known to promote Aβ pathology, recent data also support an effect of APOE …

APOEε4 is the most well-established genetic risk factor for sporadic Alzheimer's disease and
is associated with cerebral amyloid-β. However, the association between APOEε4 and tau …

Background To assess the effects of apolipoprotein E (ApoE) ε4 genotype on amyloid-β (Aβ)
and tau burden and their longitudinal changes in Alzheimer's disease (AD) spectrum …

Background Alzheimer's disease is characterized by aggregated β-amyloid and tau proteins,
but the clinical presentations and patterns of brain atrophy vary substantially. A part of this …

The apolipoprotein E ε4 (APOE ε4) allele is the most important genetic risk factor for
Alzheimer's disease (AD); however, the underlying mechanisms responsible for it remain …

Background and aims This study aims to assess the association between APOE genotype
and biomarkers of neurodegeneration in Alzheimer's disease (AD). Methods We performed …

Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer's disease and
contributes to metabolic and neuropathological abnormalities during brain aging. To provide …

Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset
Alzheimer's disease mainly by modulating amyloid-β pathology. APOE ε4 is also shown to …

Background APOE variants are strongly associated with abnormal amyloid aggregation and
additional direct effects of APOE on tau aggregation are reported in animal and human cell …

Apolipoprotein E (APOE) genotype influences onset age of Alzheimer's disease but effects
on disease progression are less clear. We investigated amyloid-β (Aβ) levels and change in …