[HTML][HTML] The influence of APOEε4 on the pTau interactome in sporadic Alzheimer's disease
M Thierry, J Ponce, M Martà-Ariza, M Askenazi… - Acta …, 2024 - Springer
APOE ε4 is the major genetic risk factor for sporadic Alzheimer's disease (AD). Although
APOE ε4 is known to promote Aβ pathology, recent data also support an effect of APOE …
APOE ε4 is known to promote Aβ pathology, recent data also support an effect of APOE …
[HTML][HTML] APOEε4 potentiates the relationship between amyloid-β and tau pathologies
APOEε4 is the most well-established genetic risk factor for sporadic Alzheimer's disease and
is associated with cerebral amyloid-β. However, the association between APOEε4 and tau …
is associated with cerebral amyloid-β. However, the association between APOEε4 and tau …
[HTML][HTML] Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease
Background To assess the effects of apolipoprotein E (ApoE) ε4 genotype on amyloid-β (Aβ)
and tau burden and their longitudinal changes in Alzheimer's disease (AD) spectrum …
and tau burden and their longitudinal changes in Alzheimer's disease (AD) spectrum …
[HTML][HTML] Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer's disease: a cohort study
Background Alzheimer's disease is characterized by aggregated β-amyloid and tau proteins,
but the clinical presentations and patterns of brain atrophy vary substantially. A part of this …
but the clinical presentations and patterns of brain atrophy vary substantially. A part of this …
Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum
The apolipoprotein E ε4 (APOE ε4) allele is the most important genetic risk factor for
Alzheimer's disease (AD); however, the underlying mechanisms responsible for it remain …
Alzheimer's disease (AD); however, the underlying mechanisms responsible for it remain …
Exploring the effect of APOE ε4 on biomarkers of neurodegeneration in Alzheimer's disease
Background and aims This study aims to assess the association between APOE genotype
and biomarkers of neurodegeneration in Alzheimer's disease (AD). Methods We performed …
and biomarkers of neurodegeneration in Alzheimer's disease (AD). Methods We performed …
[HTML][HTML] Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer's disease and
contributes to metabolic and neuropathological abnormalities during brain aging. To provide …
contributes to metabolic and neuropathological abnormalities during brain aging. To provide …
[HTML][HTML] APOE ε2 is associated with increased tau pathology in primary tauopathy
Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset
Alzheimer's disease mainly by modulating amyloid-β pathology. APOE ε4 is also shown to …
Alzheimer's disease mainly by modulating amyloid-β pathology. APOE ε4 is also shown to …
[HTML][HTML] APOE effects on regional tau in preclinical Alzheimer's disease
Background APOE variants are strongly associated with abnormal amyloid aggregation and
additional direct effects of APOE on tau aggregation are reported in animal and human cell …
additional direct effects of APOE on tau aggregation are reported in animal and human cell …
Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts
Apolipoprotein E (APOE) genotype influences onset age of Alzheimer's disease but effects
on disease progression are less clear. We investigated amyloid-β (Aβ) levels and change in …
on disease progression are less clear. We investigated amyloid-β (Aβ) levels and change in …
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