In an age when a small quantity of sperm can lead to pregnancy through in vitro fertilization
or intracytoplasmic sperm injection, selecting healthy sperm is important. Sperm DNA …

Background The initial step in the diagnostic investigation of male infertility has been
traditionally based on the conventional seminal profile. However, there are significant …

STUDY QUESTION Is there an association between high levels of sperm DNA damage and
miscarriage? SUMMARY ANSWER Miscarriage rates are positively correlated with sperm …

BACKGROUND: The extent of sperm DNA fragmentation, which can be measured by the
TUNEL assay, is one of the determinants of male fertility. However, the clinical application of …

Sperm DNA fragmentation (SDF) is becoming an important test to assess male infertility.
Several different tests are available, but no consensus has yet been reached as to which …

Objective To examine whether sperm DNA fragmentation has an effect on pregnancy and
miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI). Design Systematic …

Background Sperm chromatin integrity is essential for normal embryo development and
pregnancy outcome. Sperm DNA fragmentation (SDF) testing constitutes a diagnostic tool to …

Objective To investigate the rate of sperm DNA fragmentation in male partners of women
with recurrent pregnancy loss and fertile control women. Design Systematic review and meta …

Among the different DNA anomalies that can be present in the male gamete, DNA
fragmentation is the most frequent, particularly in infertile subjects. There is now consistent …

Over the past 25 years, various methods have been developed to measure sperm DNA
strand breaks in situ. Currently, there are four major tests of sperm DNA fragmentation …