Background This systematic review and meta-analysis explored the relationship between
vancomycin (VCM) monitoring strategies and VCM effectiveness and safety. Methods We …

Background Clinical practice guidelines or recommendations often require timely and
regular updating as new evidence emerges, because this can alter the risk-benefit trade-off …

Background and Objective The necessity of therapeutic drug monitoring (TDM) for
vancomycin is controversial. The objective of the current review was to evaluate the …

We hypothesized that dosing vancomycin to achieve trough concentrations of> 15 mg/liter
overdoses many adults compared to area under the concentration-time curve (AUC)-guided …

Evidence suggests that maintenance of vancomycin trough concentrations at between 15
and 20 mg/liter, as currently recommended, is frequently unnecessary to achieve the daily …

Vancomycin is commonly prescribed to hospitalized patients. Decades of pharmacokinetic/
pharmacodynamic research culminated in recommendations to monitor the ratio of the area …

Evidence supports vancomycin therapeutic-drug monitoring by area under the concentration-
time curve (AUC), but data to establish an AUC upper limit are limited and published …

Vancomycin is often employed as an antibacterial agent against Gram-positive bacteria,
although dose-dependent nephrotoxicity is a concern. Although the risk may be reduced by …

Abstract (See the article by Kullar et al, on pages 975-981.) Background. We sought to
characterize the pharmacodynamic profile of the more intensive vancomycin dosing …

The revised vancomycin consensus guidelines recommended area under the curve (AUC)–
guided dosing/monitoring for patients with serious invasive methicillin-resistant …