ABSTRACT NK cells control tumor and virus-infected cells through releasing cytotoxic
granules and proinflammatory cytokines. IFN-γ and TNF-α secretions and cytotoxicity are …

Abstract Interferon-γ (IFN-γ) is critical for an effective innate immune response against
infection. A combination of interleukins (ILs) derived from activated T cells (IL-2) and …

Abstract The role of Natural Killer cells in host defense against infections as well as in
tumour surveillance has been widely appreciated for a number of years. Upon recognition of …

NK cell populations were derived from murine splenocytes stimulated by IL-2, IL-15, or the
combination of IL-12 and IL-18. Whereas NK cells derived with the latter cytokines consisted …

The two major functions of human natural killer (NK) cells are conventionally associated with
distinct cell subsets. Thus, cytolytic activity is mostly confined to the CD56dimCD16+ subset …

After recognition, NK cells can kill susceptible target cells through perforin-dependent
mechanisms or by inducing death receptor-mediated apoptosis, and they can also secrete …

Previous work showed that administration of antigen-expressing apoptotic cells in vivo
results in antigen-specific CD8+ T-cell responses independent of Toll-like receptor …

We demonstrate that IL-2-activated NK cells or lymphokine-activated killer cells recognize
and kill syngeneic CD4+ and CD8+ T cells that have been activated by APCs. Induction with …

Natural killer (NK) cells directly lyse tumor or viral-infected cells but also an important role for
NK cell cytotoxicity in regulating the extent of immune responses is emerging. Here, we …

NK cells recognize and kill tumor cells and normal cells, and these play an important role in
immune defense in cancer, infectious disease, and autoimmunity. NK killing is regulated by …