Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic
without a known genetic or environmental cause. Heritable genetic predisposition …

The overall incidence of osteosarcoma is low. However, the occurrence of osteosarcoma in
a setting of multiple primary tumours is not infrequent, although population-based incidence …

Osteosarcoma is the most common primary bone malignancy, often detected in children and
adolescents and commonly associated with TP53 alterations along with a high number of …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Importance Osteosarcoma, the most common malignant bone tumor in children and
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …

Studies to determine the etiology of osteosarcoma involve epidemiologic and environmental
factors and genetic impairments. Factors related to patient characteristics include age …

Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in
children and adolescents relative to other age groups. The etiology of this often aggressive …

Osteogenic sarcoma comprises less than 0.5 per cent of all cancers. Two brothers were
recently seen who were diagnosed as having osteogenic sarcoma approximately 28 months …

Despite the knowledge of many of the genetic alterations present in osteosarcoma, its
complexity precludes placing its biology into a simple conceptual framework. In contrast to …