Gene amplification of chromosomal band 11q13 is observed frequently in oral squamous
cell carcinomas (OSCC). Several genes have been identified in the 11q13 amplicon …

Abstract Protein Phosphatase 2A (PP2A) enzymes counteract diverse kinase-driven
oncogenic pathways and their function is frequently impaired in cancer. PP2A inhibition is …

Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by PTPN11,
regulates signaling networks and cell fate in many tissues. Expression of oncogenic …

Activating mutations of the PTPN11 gene encoding the SHP2 tyrosine phosphatase is the
most common genetic abnormality in juvenile myelomonocytic leukemia and is sporadically …

Objectives: This study was to explore the effect of protein phosphatase, Mg2+/Mn2+
dependent 1D knockdown on proliferation and apoptosis as well as p38 MAPK/p53 …

Background B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by
recurrent genetic alterations including chromosomal translocations. The transcription factor …

Three novel cDNAs encoding putative protein phosphatase-1 inhibitory protein (PPP1R14A)
were isolated from human, mouse and rat. The human, mouse and rat PPP1R14A proteins …

Protein phosphatase 2A (PP2A) is one kind of serine/threonine protein phosphatase
regulating mainly cell growth and division. It comprises three subunits, A, B, and C. The B …

Background Patients with colorectal cancer (CRC) with liver metastasis or drug resistance
have a poor prognosis. Previous research has demonstrated that PPP2R1B inactivation …

In lower eukaryotic organisms, the loss of serine/threonine protein phosphatase type 1 (PP1)
results in growth arrest after the onset of mitosis. In humans, four highly homologous …