The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumatic stress disorder
M Araki, M Fuchikami, J Omura, T Miyagi… - …, 2020 - Springer
Rationale Since the precise mechanisms of posttraumatic stress disorder (PTSD) remain
unknown, effective treatment interventions have not yet been established. Numerous clinical …
unknown, effective treatment interventions have not yet been established. Numerous clinical …
Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model
K Kohda, K Harada, K Kato, A Hoshino, J Motohashi… - Neuroscience, 2007 - Elsevier
Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by
traumatic experience, and presents with characteristic symptoms, such as intrusive …
traumatic experience, and presents with characteristic symptoms, such as intrusive …
Glucocorticoids and hippocampal structure and function in PTSD
This review examines the putative link between glucocorticoid and hippocampal
abnormalities in posttraumatic stress disorder (PTSD). Increased glucocorticoid receptor …
abnormalities in posttraumatic stress disorder (PTSD). Increased glucocorticoid receptor …
[HTML][HTML] An advanced transcriptional response to corticosterone after single prolonged stress in male rats
J Ding, X Chen, F Han, OC Meijer - Frontiers in Behavioral …, 2021 - frontiersin.org
Stress-related neuropsychiatric disorders are often accompanied by dysfunction of the
hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress …
hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress …
Glucocorticoids protect against the delayed behavioral and cellular effects of acute stress on the amygdala
RP Rao, S Anilkumar, BS McEwen, S Chattarji - Biological psychiatry, 2012 - Elsevier
BACKGROUND: A single episode of acute immobilization stress has previously been shown
to trigger a delayed onset of anxiety-like behavior and spinogenesis in the basolateral …
to trigger a delayed onset of anxiety-like behavior and spinogenesis in the basolateral …
[HTML][HTML] Early handling attenuates enhancement of glucocorticoid receptors in the prefrontal cortex in an animal model of post-traumatic stress disorder
SA George, SA Stout, M Tan, D Knox… - Biology of mood & anxiety …, 2013 - Springer
Background Changes in glucocorticoid receptors (GRs) have been implicated in the
pathogenesis of stress related psychiatric disorders such as depression and post-traumatic …
pathogenesis of stress related psychiatric disorders such as depression and post-traumatic …
Glucocorticoid-and long-term stress-induced aberrant synaptic plasticity are mediated by activation of the glucocorticoid receptor
HJ Park, S Lee, JW Jung, BC Kim, JH Ryu… - Archives of pharmacal …, 2015 - Springer
Long-term stress is known to cause aberrant synaptic plasticity and to impair learning and
memory. Recent studies show that acute high concentration of glucocorticoids exerts similar …
memory. Recent studies show that acute high concentration of glucocorticoids exerts similar …
[HTML][HTML] Glucocorticoid-based pharmacotherapies preventing PTSD
Posttraumatic stress disorder (PTSD) is a highly disabling psychiatric condition that may
arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder …
arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder …
Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: relevance to post‐traumatic stress disorder
Hippocampal glucocorticoid receptors (GR and MR) play an important role in glucocorticoid
negative feedback. Abnormalities in negative feedback are found in depression and in post …
negative feedback. Abnormalities in negative feedback are found in depression and in post …
Single prolonged stress enhances hippocampal glucocorticoid receptor and phosphorylated protein kinase B levels
Animal models of posttraumatic stress disorder (PTSD) can explore neurobiological
mechanisms by which trauma enhances fear and anxiety reactivity. Single prolonged stress …
mechanisms by which trauma enhances fear and anxiety reactivity. Single prolonged stress …
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