Rationale Since the precise mechanisms of posttraumatic stress disorder (PTSD) remain
unknown, effective treatment interventions have not yet been established. Numerous clinical …

Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by
traumatic experience, and presents with characteristic symptoms, such as intrusive …

This review examines the putative link between glucocorticoid and hippocampal
abnormalities in posttraumatic stress disorder (PTSD). Increased glucocorticoid receptor …

Stress-related neuropsychiatric disorders are often accompanied by dysfunction of the
hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress …

BACKGROUND: A single episode of acute immobilization stress has previously been shown
to trigger a delayed onset of anxiety-like behavior and spinogenesis in the basolateral …

Background Changes in glucocorticoid receptors (GRs) have been implicated in the
pathogenesis of stress related psychiatric disorders such as depression and post-traumatic …

Long-term stress is known to cause aberrant synaptic plasticity and to impair learning and
memory. Recent studies show that acute high concentration of glucocorticoids exerts similar …

Posttraumatic stress disorder (PTSD) is a highly disabling psychiatric condition that may
arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder …

Hippocampal glucocorticoid receptors (GR and MR) play an important role in glucocorticoid
negative feedback. Abnormalities in negative feedback are found in depression and in post …

Animal models of posttraumatic stress disorder (PTSD) can explore neurobiological
mechanisms by which trauma enhances fear and anxiety reactivity. Single prolonged stress …