The homeobox gene Pitx2 has been characterized as a mediator of left-right signaling in
heart, gut, and lung morphogenesis. However, the relationship between the developmental …

The Pitx2 gene regulates left-right (L/R) asymmetrical cardiac morphogenesis. Constitutive
Pitx2 knock out (ko) mice die before birth and display, among other defects, right atrial …

Pitx2 is a bicoid-related homeodomain transcription factor that plays a critical role in
directing cardiac asymmetric morphogenesis. Ectopic Pitx2c expression in the developing …

Cardiac development is a complex morphogenetic process initiated as bilateral cardiogenic
mesoderm is specified at both sides of the gastrulating embryo. Soon thereafter, these …

The pitx2 gene is a member of the bicoid-homeodomain class of transcription factors that
has been implicated in the control of left-right asymmetry during organogenesis. Here we …

To aid in detection and tracking of cells targeted by the left‐right (LR) pathway in the heart
throughout morphogenesis, expression from a Pitx2c‐lacZ transgene (P2Ztg) was analysed …

Current models of left–right asymmetry hold that an early asymmetric signal is generated at
the node and transduced to lateral plate mesoderm in a linear signal transduction cascade …

The homeobox transcription factor Pitx2 displays a highly specific expression pattern during
embryogenesis. Gain and loss of function experiments have unraveled its pivotal role in left …

The Pitx2 gene encodes a homeobox transcription factor that is required for mammalian
development. Disruption of PITX2 expression in humans causes congenital heart diseases …

Inactivation of the left-right asymmetry gene Pitx2 has been shown, in mice, to result in right
isomerism with associated defects that are similar to that found in humans. We show that the …