There is great interest in discovering targets for in vitro manipulation of autologous T cells
that enhance their cytotoxicity against tumor targets as a potent cancer immunotherapy. In a …

Tumor-infiltrating T cells often lose their effector function; however, the mechanisms are
incompletely understood. We report that cholesterol in the tumor microenvironment induces …

CD8+ T cells can be polarized into IL-9–secreting (Tc9) cells. We previously showed that
adoptive therapy using tumor-specific Tc9 cells generated stronger antitumor responses in …

Despite the advances in immunotherapies, effective against some types of cancer,
progression of several types of carcinoma remains uncurable. Recent studies indicate that …

As an essential part of adaptive immunity, T cells coordinate the immune responses against
pathogens and cancer cells. Lipid metabolism has emerged as a key regulator for the …

CD8+ T cells have a central role in antitumour immunity, but their activity is suppressed in
the tumour microenvironment,,,. Reactivating the cytotoxicity of CD8+ T cells is of great …

The concept of targeting cholesterol metabolism to treat cancer has been widely tested in
clinics, but the benefits are modest, calling for a complete understanding of cholesterol …

After antigenic activation, quiescent naive CD4+ T cells alter their metabolism to proliferate.
This metabolic shift increases production of nucleotides, amino acids, fatty acids, and …

Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Cell signaling for T-cell growth, differentiation, and apoptosis is initiated in the cholesterol-
rich microdomains of the plasma membrane known as lipid rafts. Herein, we investigated …