Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring

MD Bauman, AM Iosif, SEP Smith, C Bregere… - Biological …, 2014 - Elsevier
Background Maternal infection during pregnancy is associated with an increased risk of
schizophrenia and autism in the offspring. Supporting this correlation, experimentally …

Maternal immune activation: Implications for neuropsychiatric disorders

ML Estes, AK McAllister - Science, 2016 - science.org
Epidemiological evidence implicates maternal infection as a risk factor for autism spectrum
disorder and schizophrenia. Animal models corroborate this link and demonstrate that …

Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness

PH Patterson - Current opinion in neurobiology, 2002 - Elsevier
Direct viral infection of the developing brain can have disastrous consequences for the fetus.
More subtle and perhaps more insidious are viral infections of the pregnant mother, which …

[HTML][HTML] Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and …

MB Hall, DE Willis, EL Rodriguez… - Frontiers in …, 2023 - frontiersin.org
Epidemiological evidence suggests that one's risk of being diagnosed with a
neurodevelopmental disorder (NDD)—such as autism, ADHD, or schizophrenia—increases …

Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex

DA Amodeo, CY Lai, O Hassan, EA Mukamel… - Neurobiology of …, 2019 - Elsevier
Background Epidemiological studies suggest that the risk of neurodevelopmental disorders
such as autism spectrum disorder (ASD) and schizophrenia is increased by prenatal …

The role of maternal immune activation in altering the neurodevelopmental trajectories of offspring: A translational review of neuroimaging studies with implications for …

E Guma, E Plitman, MM Chakravarty - Neuroscience & Biobehavioral …, 2019 - Elsevier
Exposure to maternal infection in utero increases the risk that offspring will develop
neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia …

[HTML][HTML] Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice

JJ Schwartzer, M Careaga, CE Onore… - Translational …, 2013 - nature.com
It is becoming increasingly apparent that the causes of autism spectrum disorders (ASD) are
due to both genetic and environmental factors. Animal studies provide important …

[HTML][HTML] Maternal and early postnatal immune activation produce sex-specific effects on autism-like behaviors and neuroimmune function in mice

WA Carlezon Jr, W Kim, G Missig, BC Finger… - Scientific reports, 2019 - nature.com
Increasing evidence suggests a role for inflammation in neuropsychiatric conditions
including autism spectrum disorder (ASD), a neurodevelopmental syndrome with higher …

[HTML][HTML] Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder

MV Lombardo, HM Moon, J Su, TD Palmer… - Molecular …, 2018 - nature.com
Maternal immune activation (MIA) via infection during pregnancy is known to increase risk
for autism spectrum disorder (ASD). However, it is unclear how MIA disrupts fetal brain gene …

Maternal immune activation causes age-and region-specific changes in brain cytokines in offspring throughout development

PA Garay, EY Hsiao, PH Patterson… - Brain, behavior, and …, 2013 - Elsevier
Maternal infection is a risk factor for autism spectrum disorder (ASD) and schizophrenia (SZ).
Indeed, modeling this risk factor in mice through maternal immune activation (MIA) causes …