Intracellular delivery of biological agents such as peptides, proteins, and nucleic acids
generally rely on the endocytic pathway as the major uptake mechanism, resulting in their …

Cell delivery reagents often exploit the endocytic pathway as a route of cell entry. Once
endocytosed, these reagents must overcome endosomal entrapment to ensure the release …

Ineffective cellular delivery is a common problem in numerous biological applications.
Developing delivery reagents that work robustly in a variety of experimental settings remains …

Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …

Despite continuous improvements in delivery systems, the development of methods for
efficient and specific delivery of targeted therapeutic agents still remains an issue in …

With advances in therapeutic science, apart from drugs, newer bioactive moieties like
oligonucleotides, proteins, peptides, enzymes and antibodies are constantly being …

Protein-based therapeutics have unique therapeutic potential due to their specificity,
potency, and low toxicity. The vast majority of intracellular applications of proteins require …

Many emerging therapies rely on the delivery of biological cargo into the cytosol.
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …

Advances in the delivery of targeted drug systems have evolved to enable highly regulated
site specific localization to subcellular organelles. Targeting therapeutics to individual …

Conspectus Over the past decades, major efforts were undertaken to develop devices on a
nanoscale level for the efficient and nontoxic delivery of molecules to tissues and cells, for …